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The Centre for Allergy Research

Newsletter 13 December 2018

Have a Happy St. Lucia Day!
 

 

ChAMP Annual Retreat

Rånäs Slott 20-21 November

The ChAMP team at Rånäs Slott

The ChAMP (CfA highlights Asthma Markers of Phenotype) project had its annual retreat at Rånäs Slott on 20-21 November 2018 with about 60 participants, including international collaborators from the UK, Poland, France, Denmark and Switzerland.

Because the project during the past five years has developed and applied new panels for biomarker measurements, the focus of many of the presentations and discussions during the retreat was on how to integrate complex heterogeneous data to produce biomarker profiles linked to specific asthma phenotypes. Results were shown from the U-BIOPRED, BIOAIR, Swedish GA2LEN and Wessex studies, and the newly started study BIOCROSS was also presented.

Irrespective of the input used for clustering of data (e.g profiles of markers in blood, sputum, or urine) certain clinically distinct molecular subgroups (e.g. typical type 2 inflammation, obesity related asthma, high IL6-trans signaling, inflammasome-associated, etc) were replicated using different strategies. Moreover, the development of new and more predictive experimental models for studies of mechanisms in asthma were also reported and discussed. The ultimate goal of the project is to achieve better biomarkers to support the implementation of personalised treatments for asthma.

The ChAMP project is co-ordinated by the CfA and receives funding from the Swedish Strategic Foundation, Astra Zeneca, the Stockholm County Council Research Funds, the Swedish Heart Lung Foundation, and the Swedish Medical Research Council.

A short presentation of the biomarker panels

The ChAMP project
 

Food Allergy Theme in the KI magazine

Medical Science (Medicinsk Vetenskap)

The popular science magazine Medical Science (Medicinsk Vetenskap), published by Karolinska Institutet, has included a series of articles on food allergy research in its latest issue. The articles can also be read on the KI website, in both Swedish and English. Several CfA-affiliated researchers are interviewed, among which Caroline Nilsson, Erik Melén, Jennifer Protudjer, Marianne van Hage and Björn Nordlund, about the latest research findings as well as on ongoing studies. A guide to the different food allergies and intolerances is also included.

Theme: Food Allergy
 

Upcoming CfA seminars

 

17th January 2019: Peter Howarth
The airway microbiome and severe asthma

Speaker: Prof. Peter Howarth, Faculty of Medicine, University of Southampton and NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, United Kingdom
Time: 16:00, 17th January 2018
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 15:30


21st February 2019: Brian Lipworth
Use of impulse oscillometry in asthma and COPD

Speaker: Prof. Brian Lipworth, Scottish Centre for Respiratory Research, Division of Molecular and Clinical Medicine, University of Dundee, United Kingdom
Time: 16:00, 21st February 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 15:30


7th March 2019: Parameswaran Nair
Treating asthma using sputum cells and biomarkers for diagnosis and phenotyping

Speaker: Prof. Parameswaran Nair, Division of Respirology, Firestone Institute for Respiratory Health, St Joseph's Healthcare, McMaster University, Hamilton, Canada
Time: 16:00, 7th March 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 15:30
 

Report from Food Allergy Conference 11th October

The Project Manager for Good food for all, Sofia Knáz, presented the project at the conference.

On 11th October the Swedish Nutrition Foundation organised a Food Allergy Conference in Stockholm, in collaboration with the Good food for all (Bra mat för alla) project. 120 participants listened to presentations on food allergy covering a variety of topics, ranging from prevalence, diagnosis, treatment, quality of life, nutrition to labelling of food products.

Report from the conference on the Swedish Food Federation website


About the Good food for all project

The Good food for all (Bra mat för alla) project is a collaboration between the Centre for Allergy Research, the Asthma and Allergy Association and the Swedish Food Federation. Together, we will build up a national centre of excellence with the ultimate goal to improve the quality of life of persons with food hypersensitivity.

The centre will be established with funding from the Swedish Arvsfonden. Read more about Good food for all on on CfA's website and at the Asthma and Allergy Association's site.

Contact person: Sofia Knáz, Asthma and Allergy Association
 

Opinion article in medical newspaper Dagens Medicin:

Acute shortage of allergologists and pulmonologists

The number of allergologists in Stockholm County that are under the age of 65, from 2010 to 2020. Currently, 53% of the allergologists are over 65. Photo: Thinkstock, Maria Hammar, Dagens Medicin

Recently, an opinion article was published in the Swedish medical newspaper Dagens Medicin by Cecilia Bredin, Anders Lindén, Apostolos Bossios, Barbro Dahlén, Giovanni Ferrara, Johan Grunewald, Magnus Sköld och Victoria Strand.

The article describes the urgent shortage of allergologists and pulmonologists in Sweden, which is a serious problem that will have a substantial impact on the health of patients with severe allergies and pulmonary disease, both at a regional and a national level.

Acute shortage of allergologist and pulmonologists (in Swedish)
 

Congratulations!

 

Casper Wahlund

 

Casper Wahlund
Who successfully defended his thesis on 12th October 2018.

Title: Extracellular vesicles – mediators of immune modulation in the lungs and as therapeutic vehicles
Dept. of Medicine Solna
Main supervisor: Susanne Gabrielsson

Opponent: Professor Olov Ekwall, Dept. of Medicine, University of Gothenburg, Sahlgrenska University Hospital

Anna Steneholm
Who successfully defended her thesis on 26th October 2018.

Title: Innate immune airway responses after exposure to ultrafine and ambient particles: In vivo and in vitro models
Institute of Environmental Medicine
Supervisors: Lena Palmberg, Kjell Larsson, Per Gerde, Maciej Kupczyk

Opponent: Professor Hans Jürgen Hoffmann, Dept. of Clinical Medicine, Dept of Respiratory Diseases and Allergy, Aarhus University, Denmark

From left to right: Per Gerde, Anna Steneholm, Lena Palmberg (main supervisor), Britt-Marie Sundblad, Kjell Larsson.
 

Konsul Th C Bergh's Foundation invites to a scientific symposium 28th March:

Precision Medicine in Allergy and Asthma – New Possibilities?


Venue: Svenska Läkaresällskapet, Stockholm
Time: 28th March 9:15-16:30
Registration fee: 300 SEK

Internationally renowned researchers from Sweden and abroad will present and discuss the latest research findings in the area of precision medicine. On the speakers' list are, among others, Elisabeth Bel, Klaus Bønnelykke and Rudolf Valenta.

Organising committee: Gunilla Hedlin, Marianne van Hage, Arne Egesten and Lars Hellman

Symposium Precision Medicine in Allergy and Asthma - New Possibilities?
 

Upcoming thesis defences in the

asthma and allergy area

 

22nd February 2019: Nikolaos Lazarinis
Dept. of Medicine Huddinge

Title: Bronchoprovocation studies to define mechanisms in asthma and airway inflammation

Main supervisor: Barbro Dahlén, Co-supervisors: Sven-Erik Dahlén, Craig Wheelock
Opponent: Professor Brian Lipworth, University of Dundee, Scottish Centre for Respiratory Research, Division of Molecular and Clinical Medicine, United Kingdom

Time: 9:00
Venue: Lecture Hall C1:87, Karolinska University Hospital, Huddinge
 

The Konsul Th C Bergh's Foundation welcomes applications for research funding


The Konsul Th C Berghs Foundation gives financial support to allergy research in Sweden, with up to 1 million SEK each year. Researchers can apply for project funding and stipends. The Foundation prioritises researchers at an early stage in their careers and PhD students. A special grant is awarded to a researcher who has defended his or her thesis during 2017-2018.
Application deadline: 14th December 2018

Konsul Th C Bergh's Foundation
 

Recent publications by CfA researchers
 

Identification and prospective stability of eNose derived inflammatory phenotypes in severe asthma. Brinkman P, Wagener AH, Hekking PP, Bansal AT, Maitland-van der Zee AH, Wang Y, Weda H, Knobel HH, Vink TJ, Rattray NJ, D'Amico A, Pennazza G, Santonico M, Lefaudeux D, De Meulder B, Auffray C, Bakke PS, Caruso M, Chanez P, Chung KF, Corfield J, Dahlén SE, Djukanovic R, Geiser T, Horvath I, Krug N, Musial J, Sun K, Riley JH, Shaw DE, Sandström T, Sousa AR, Montuschi P, Fowler SJ, Sterk PJ; U-BIOPRED Study Group. J Allergy Clin Immunol. 2018 Dec 5. pii: S0091-6749(18)31722-6. doi: 10.1016/j.jaci.2018.10.058. [Epub ahead of print]

Exosomes and cells from lung cancer pleura exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1. Lukic A, Wahlund CJE, Gomez C, Brodin D, Samuelsson B, Wheelock CE, Gabrielsson S, Radmark O. Cancer Lett. 2018 Nov 30. pii: S0304-3835(18)30699-2. doi: 10.1016/j.canlet.2018.11.033. [Epub ahead of print]

Smoking habits among adolescents with asthma - data from a population based birth cohort. Hellberg U, Thacher JD, Andersson N, Pershagen G, Melén E, Bergström A, Kull I. Allergy. 2018 Dec 4. doi: 10.1111/all.13694. [Epub ahead of print]

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study. Sjödin MOD, Checa A, Yang M, Dahlén SE, Wheelock ÅM, Eklund A, Grunewald J, Wheelock CE. Respir Res. 2018 Dec 3;19(1):236. doi: 10.1186/s12931-018-0939-0.

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy. Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA. Clin Exp Allergy. 2018 Dec;48(12):1606-1621. doi: 10.1111/cea.13318. Review.

Atopic dermatitis at preschool age and contact allergy in adolescence: a population-based cohort study. Lagrelius M, Wahlgren CF, Matura M, Bergström A, Kull I, Lidén C. Br J Dermatol. 2018 Nov 22. doi: 10.1111/bjd.17449. [Epub ahead of print]

Influence of contextual factors on quality of primary care in children with asthma. Ingemansson M, Jonsson M, Henriksson P, Hedlin G, Kull I, Wikström Jonsson E, Krakau I, Kiessling A. J Eval Clin Pract. 2018 Nov 21. doi: 10.1111/jep.13078. [Epub ahead of print]

Short contact with nickel is not harmless. Ahlström MG, Thyssen JP, Menné T, Lidén C. Contact Dermatitis. 2018 Nov 18. doi: 10.1111/cod.13159. [Epub ahead of print]

Dog characteristics and future risk of asthma in children growing up with dogs. Fall T, Ekberg S, Lundholm C, Fang F, Almqvist C. Sci Rep. 2018 Nov 15;8(1):16899. doi: 10.1038/s41598-018-35245-2.

New insights into the origin of mast cells. Nilsson G, Dahlin JS. Allergy. 2018 Nov 14. doi: 10.1111/all.13668. [Epub ahead of print]

Dividing neutrophils in subsets, reveals a significant role for activated neutrophils in the development of airway hyperreactivity. Ekstedt S, Säfholm J, Georén SK, Cardell LO. Clin Exp Allergy. 2018 Nov 11. doi: 10.1111/cea.13311. [Epub ahead of print]

Allergen-specific IgE over time in women before, during and after pregnancy. Hedman AM, Lundholm C, Scheynius A, Alm J, Andolf E, Pershagen G, Almqvist C. Allergy. 2018 Nov 8. doi: 10.1111/all.13662. [Epub ahead of print]

MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence. Bousquet J, Arnavielhe S, Bedbrook A, Bewick M, Laune D, Mathieu-Dupas E, Murray R, Onorato GL, Pépin JL, Picard R, Portejoie F, Costa E, Fonseca J, Lourenço O, Morais-Almeida M, Todo-Bom A, Cruz AA, da Silva J, Serpa FS, Illario M, Menditto E, Cecchi L, Monti R, Napoli L, Ventura MT, De Feo G, Larenas-Linnemann D, Fuentes Perez M, Huerta Villabolos YR, Rivero-Yeverino D, Rodriguez-Zagal E, Amat F, Annesi-Maesano I, Bosse I, Demoly P, Devillier P, Fontaine JF, Just J, Kuna TP, Samolinski B, Valiulis A, Emuzyte R, Kvedariene V, Ryan D, Sheikh A, Schmidt-Grendelmeier P, Klimek L, Pfaar O, Bergmann KC, Mösges R, Zuberbier T, Roller-Wirnsberger RE, Tomazic P, Fokkens WJ, Chavannes NH, Reitsma S, Anto JM, Cardona V, Dedeu T, Mullol J, Haahtela T, Salimäki J, Toppila-Salmi S, Valovirta E, Gemicioğlu B, Yorgancioglu A, Papadopoulos N, Prokopakis EP, Bosnic-Anticevich S, O'Hehir R, Ivancevich JC, Neffen H, Zernotti E, Kull I, Melen E, Wickman M, Bachert C, Hellings P, Palkonen S, Bindslev-Jensen C, Eller E, Waserman S, Sova M, De Vries G, van Eerd M, Agache I, Casale T, Dykewickz M, Naclerio RN, Okamoto Y, Wallace DV; MASK study group. Clin Transl Allergy. 2018 Oct 25;8:45. doi: 10.1186/s13601-018-0227-6. eCollection 2018. Review.

Tape stripping alters the microbe-host correlations in mouse skin. Karisola P, Suomalainen A, Fortino V, Ottman N, Vendelin J, Wolff HJ, Ruokolainen L, Greco D, Fyhrquist N, Alenius H. Allergy. 2018 Oct 29. doi: 10.1111/all.13653. [Epub ahead of print]

Fixed airflow obstruction relates to eosinophil activation in asthmatics. Mogensen I, Alving K, Dahlen SE, James A, Forsberg B, Ono J, Ohta S, Venge P, Borres MP, Izuhara K, Janson C, Malinovschi A. Clin Exp Allergy. 2018 Oct 26. doi: 10.1111/cea.13302. [Epub ahead of print]

An Optimized Protocol for the Isolation and Functional Analysis of Human Lung Mast Cells. Ravindran A, Rönnberg E, Dahlin JS, Mazzurana L, Säfholm J, Orre AC, Al-Ameri M, Peachell P, Adner M, Dahlén SE, Mjösberg J, Nilsson G. Front Immunol. 2018 Oct 5;9:2193. doi: 10.3389/fimmu.2018.02193. eCollection 2018.

Impact of IgE sensitization and rhinitis on inflammatory biomarkers and lung function in adolescents with and without asthma. Hallberg J, Ballardini N, Almqvist C, Westman M, van Hage M, Lilja G, Bergström A, Kull I, Melén E. Pediatr Allergy Immunol. 2018 Oct 20. doi: 10.1111/pai.12994. [Epub ahead of print]

Placental inflammation, lifestyle, maternal and early child sensitisation to allergens - the assessment of lifestyle and allergic disease during infancy birth cohort. Papadogiannakis N, Joerink M, Rindsjö E, Scheynius A, Alm J. Acta Paediatr. 2018 Oct 18. doi: 10.1111/apa.14618. [Epub ahead of print]

Pediatric asthma: An unmet need for more effective, focused treatments. Papadopoulos NG, Čustović A, Cabana MD, Dell SD, Deschildre A, Hedlin G, Hossny E, Le Souëf P, Matricardi PM, Nieto A, Phipatanakul W, Pitrez PM, Pohunek P, Gavornikova M, Jaumont X, Price DB. Pediatr Allergy Immunol. 2018 Oct 12. doi: 10.1111/pai.12990. [Epub ahead of print] Review.

Parental nicotine replacement therapy and offspring bronchitis/bronchiolitis and asthma - a nationwide population-based cohort study. Molero Y, Zetterqvist J, Lichtenstein P, Almqvist C, Ludvigsson JF. Clin Epidemiol. 2018 Sep 25;10:1339-1347. doi: 10.2147/CLEP.S171401. eCollection 2018

Treatable traits in the European U-BIOPRED adult asthma cohorts. Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Allergy. 2018 Oct 11. doi: 10.1111/all.13629. [Epub ahead of print]

Purification and Characterization of Naturally Occurring Post-Translationally Cleaved Ara h 6, an Allergen That Contributes Substantially to the Allergenic Potency of Peanut. de Jong GAH, Jayasena S, Johnson P, Marsh J, Apostolovic D, van Hage M, Nordlee J, Baumert J, Taylor SL, Roucairol C, de Jongh H, Koppelman SJ. J Agric Food Chem. 2018 Oct 17;66(41):10855-10863. doi: 10.1021/acs.jafc.8b03140. Epub 2018 Oct 4.

Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis. Jonstam K, Swanson BN, Mannent L, Cardell LO, Tian N, Wang Y, Zhang D, Fan C, Holtappels G, Hamilton JD, Grabher A, Graham NMH, Pirozzi G, Bachert C. Allergy. 2018 Nov 28. doi: 10.1111/all.13685. [Epub ahead of print]

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma.Reinke SN, Galindo-Prieto B, Skotare T, Broadhurst DI, Singhania A, Horowitz D, Djukanović R, Hinks TSC, Geladi P, Trygg J, Wheelock CE.Anal Chem. 2018 Nov 20;90(22):13400-13408. doi: 10.1021/acs.analchem.8b03205. Epub 2018 Nov 2.

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability. Daskalaki E, Pillon NJ, Krook A, Wheelock CE, Checa A. Anal Chim Acta. 2018 Dec 11;1037:338-350. doi: 10.1016/j.aca.2018.04.034. Epub 2018 Apr 18.
 

Upcoming conferences and meetings
in the asthma and allergy area

 

18th Fraunhofer Seminar Translational Airway Research "Models of Lung Disease", 24-25 January 2019, Hannover, Germany

AAAAI Annual Meeting, 22-25 February 2019, San Francisco, USA

ERS Lung Science Conference "Mechanisms of acute exacerbation of respiratory disease", 7-10 March 2019, Estoril, Portugal

Lund Respiratory Network (LURN) Meeting "Inflammation in the lung", 21-22 March 2019, Ystad, Sweden

RHINA, European Rhinallergy Meeting, 21-23 March 2019, Eastbourne, United Kingdom

Konsul Th C Bergh's Foundation Scientific Symposium: Precision Medicine in Allergy and Asthma – New Possibilities?, 28 March 2018, Stockholm, Sweden

SAM, Skin Allergy Meeting, 4-6 April 2019, Munich, Germany

ATS Annual Conference, 17-22 May 2019, Dallas, USA

EAACI Annual Congress, 1-5 June 2019, Lisbon, Portugal

9th meeting of the European Mast Cell and Basophil Research Network (EMBRN), 17-19 June 2019, Uppsala, Sweden

ERS International Congress, 28 September-2 October 2019, Madrid, Spain

EAACI PAAM (Pediatric Allergy and Asthma Meeting), 17-19 October 2019, Florence, Italy

16th International Conference "Bioactive Lipids in Cancer, Inflammation and Related Diseases", 20-23 October 2019, St. Petersburg, Florida, USA
 

About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy. ki.se/cfa

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Read about how we treat your personal data at CfA's website. If you do not wish to receive the newsletter any longer, please click "unsubscribe" at the top of this newsletter. If you wish to subsribe to this newsletter, please contact Roelinde.Middelveld@ki.se. By doing so, you consent to treatment of your personal data as described here.

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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Roelinde Middelveld
kontakt: ki.se/cfa e-mail: cfa@imm.ki.se

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