Upcoming CfA seminars

7th March 2019: Parameswaran Nair
Treating asthma using sputum cells and biomarkers for diagnosis and phenotyping

Speaker: Prof. Parameswaran Nair, Division of Respirology, Firestone Institute for Respiratory Health, St Joseph's Healthcare, McMaster University, Hamilton, Canada
Time: 16:00, 7th March 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 15:30

Welcome!

About the speaker:

A selection of Dr. Nair's recent publications:

Nair P, O'Byrne PM. The interleukin-13 paradox in asthma: effective biology, ineffective biologicals. Eur Respir J. 2019 Jan 31;53(2). pii: 1802250. doi: 10.1183/13993003.02250-2018. Print 2019 Feb. PubMed PMID: 30760544.

Bhalla A, Mukherjee M, Nair P. Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma. Immunol Allergy Clin North Am. 2018 Nov;38(4):639-654. doi: 10.1016/j.iac.2018.06.003. Epub 2018 Sep 21. Review. PubMed PMID: 30342585.

Mukherjee M, Thomas SR, Radford K, Dvorkin-Gheva A, Davydchenko S, Kjarsgaard M, Svenningsen S, Almas S, Felix LC, Stearns J, Li QZ, Khalidi N, Lacy P, Nair PK. Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody-Negative Eosinophilic Granulomatosis with Polyangiitis. Am J Respir Crit Care Med. 2019 Jan 15;199(2):158-170. doi: 10.1164/rccm.201804-0809OC. PubMed PMID: 30179583.

Rabe KF, Nair P, Brusselle G, Maspero JF, Castro M, Sher L, Zhu H, Hamilton JD, Swanson BN, Khan A, Chao J, Staudinger H, Pirozzi G, Antoni C, Amin N, Ruddy M, Akinlade B, Graham NMH, Stahl N, Yancopoulos GD, Teper A. Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma. N Engl J Med 2018; 378: 2475-2485

Sehmi R, Lim HF, Mukherjee M, Huang C, Radford K, Newbold P, Boulet LP, Dorscheid D, Martin JG, Nair P. Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma. J Allergy Clin Immunol 2018; 141: 1529-1532.e8.

Svenningsen S, Eddy RL, Lim HF, Cox PG, Nair P, Parraga G. Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. Am J Respir Crit Care Med 2018; 197: 876-884.

Mukherjee M, Bulir DC, Radford K, Kjarsgaard M, Huang CM, Jacobsen EA, Ochkur SI, Catuneanu A, Lamothe-Kipnes H, Mahony J, Lee JJ, Lacy P, Nair P. Sputum autoantibodies in patients with severe eosinophilic asthma. J Allergy Clin Immunol 2018; 141: 1269-1279.

Mukherjee M, Aleman Paramo F, Kjarsgaard M, Salter B, Nair G, LaVigne N, Radford K, Sehmi R, Nair P. Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab. Am J Respir Crit Care Med 2018; 197: 38-46.

Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, Barker P, Sproule S, Ponnarambil S, Goldman M; ZONDA Trial Investigators. Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma. N Engl J Med 2017 May 22. doi: 10.1056/NEJMoa1703501. [Epub ahead of print]

CfA seminar

15th April 2019: Anke-Hilse Maitland-van der Zee

Precision Medicine in respiratory disease, are we beyond fiction?

Speaker: Prof. Anke-Hilse Maitland-van der Zee, Professor of Precision Medicine in Respiratory Disease, Department of Respiratory Medicine and Department of Pediatric Respiratory Medicine, Amsterdam University Medical Centre, the Netherlands
Time: 16:00, 15th April 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Hosts: Bronwyn Haasdyk Brew, Dept. of Medical Epidemiology and Biostatistics, and Erik Melén, Institute of Environmental Medicine
Coffee and tea served 15:30

Congratulations!

The project will be coordinated by Professor Marta Alarcón-Riquelme, Fundación Pública Andaluza Progreso y Salud, Spain. She is also foreign adjunct professor at the Institute of Environmental Medicine at KI. 3TR has 70 partners (including universities, pharmaceutical companies, universities, SME’s, societies and patient organisations). The total budget will be 80 million EUR, of which 40 million EUR is contributed by the pharmaceutical industry.

The project is estimated to start August 2019 and will run for 7 years. The contributions to the project in Stockholm by Karolinska Institutet, Karolinska University Hospital and the Science for Life Laboratory will be coordinated by Sven-Erik Dahlén.

The "Good food for all" project is looking for persons with food allergies and food hypersensitivity to contribute to the national centre that is being built up

Do you have physician-diagnosed food allergy or food hypersensitivity and would like to get involved in supporting the national centre of excellence "Good food for all" (Bra mat för alla)?

"Good food for all" is now looking for persons to include in a reference group of patients with food allergy and food hypersensitivity. Participation in this group will mean you will be asked for your input and advice during the course of the project, and to participate in meetings, workshops and surveys.

The main goal of "Good food for all" is to create a transdisciplinary, multisectorial, national centre of excellence for food allergy and other hypersensitivity to food in Sweden.

Register your interest at the latest 25th February

More about "Good food for all"

9th EMBRN International Mast Cell and Basophil Meeting – A Marcus Wallenberg Symposium -
17-19 June 2019

Welcome to the 9th EMBRN (European Mast Cell and Basophil Research Network) Meeting - A Marcus Wallenberg symposium, which will be held 17-19 June 2019. The meeting will be held in the Old University building in Uppsala, which is ideally located in the old part of the Uppsala city centre.

The programme will cover many topics of mast cell and basophil biology, for example their involvement in cancer and respiratory diseases. The number of participants is limited to 200.

There will be a limited number of travel awards available for students. When you register, you will have the possibility to indicate that you apply for a travel award; these will be awarded based on submitted abstracts.

Registration is now open. Abstract submission deadline: 1st March 2019

Conference website

The EMBRN 2019 committee consists of: Gunnar Pejler, Jenny Hallgren, Magnus Åbrink, Sara Wernersson, Lars Hellman and Gunnar Nilsson

Save the date: KiiM Retreat 3-4 October 2019

This year's KiiM retreat which will be held at Skogshem and Wijk on Lidingö 3-4 October. All the people involved in KiiM and Aii are currently working on the programme.

Are you a PhD student and want to help out?

Since this is an important and appreciated event for immunology doctoral students and usually there are around 70 students attending, doctoral students are encouraged to participate in the planning and organization! We are now looking for 2-3 doctoral students to join the KiiM 2019 organising committee!

This will be a great opportunity to network, gain experience of event planning, and make the 2019 KiiM retreat the best doctoral student retreat (+ it looks good on your CV).

Please contact one of the following persons if you are interested: caroline.gronwall@ki.se, stephen.malin@ki.se or mikael.karlsson@ki.se

Upcoming thesis defence in the

asthma and allergy area

22nd February 2019: Nikolaos Lazarinis
Dept. of Medicine Huddinge

Title: Bronchoprovocation studies to define mechanisms in asthma and airway inflammation

Main supervisor: Barbro Dahlén, Co-supervisors: Sven-Erik Dahlén, Craig Wheelock
Opponent: Professor Brian Lipworth, University of Dundee, Scottish Centre for Respiratory Research, Division of Molecular and Clinical Medicine, United Kingdom

Time: 9:00
Venue: Lecture Hall C1:87, Karolinska University Hospital, Huddinge

8th March 2019: Elin Dahlén
Dept. of Medicine Solna

Title: Drug utilization in children with asthma – methodological approaches and practical implications

Main supervisor: Björn Wettermark, Co-supervisors: Inger Kull, Eva Wikström Jonsson, Catarina Almqvist Malmros
Opponent: Professor Eric van Ganse, Claude-Bernard Lyon1 University
Pharmacoepidemiology / Health Services and Performance Research
(HESPER); Croix Rousse University Hospital, Lyon, France Respiratory Medicine
Patient Self-Management Training Unit, France

Time: 9:00
Venue: Norrbacka, Rehabsalen S2:01, Karolinska University Hospital, Solna

The Swedish Society for Allergology (SFFA)
Annual Meeting 2nd April, Aula Medica, KI

The Swedish Society for Allergology (SFFA) will hold its annual meeting in Aula Medica, Karolinska Institutet, on 2nd April. Speakers, among others, are Barbro Dahlén, Anna Nopp, Ulrika Käck, Nils Hamnerius and Helena Thulin. Moderators: Pär Gyllfors and Björn Stridh.

SFFA Annual Meeting programme and registration

The Swedish Lung Congress, 3-5 April, Aula Medica, KI

The Swedish Lung Congress will take place at Aula Medica, Karolinska Institutet, 3-5 April 2019. Sessions will focus on chronic lung disease, including chronic airway obstruction, sarcoidosis and severe asthma. A "hot topics" session will present the latest in precision medicine in lung cancer and new treatment guidelines for Idiopathic Pulmonary Fibrosis.

Register at the latest 22nd February for the lower registration fee

Swedish Lung Congress programme and registration

Recent publications by CfA researchers
 

Health-related quality of life worsens by school age amongst children with food allergy. Thörnqvist V, Middelveld R, Wai HM, Ballardini N, Nilsson E, Strömquist J, Ahlstedt S, Nilsson LJ, Protudjer JLP. Clin Transl Allergy. 2019 Feb 7;9:10. doi: 10.1186/s13601-019-0244-0. eCollection 2019. PubMed PMID: 30774928; PubMed Central PMCID: PMC6366088.

Academic achievement of adolescents with asthma or atopic disease. Brew BK, Söderberg J, Lundholm C, Afshar S, Holmberg K, Almqvist C. Clin Exp Allergy. 2019 Feb 16. doi: 10.1111/cea.13371. [Epub ahead of print] PubMed PMID: 30771249.

DNA methylation and allergic sensitizations, a genome-scale longitudinal study during adolescence.Zhang H, Kaushal A, Merid SK, Melen E, Pershagen G, Rezwan FI, Han L, Ewart S, Arshad SH, Karmaus W, Holloway JW. Allergy. 2019 Feb 14. doi: 10.1111/all.13746. [Epub ahead of print] PubMed PMID: 30762239.

Parental asthma and risk of autism spectrum disorder in offspring: a population and family based case-control study. Gong T, Lundholm C, Rejnö G, Bölte S, Larsson H, D'Onofrio BM, Lichtenstein P, Almqvist C. Clin Exp Allergy. 2019 Feb 11. doi: 10.1111/cea.13353. [Epub ahead of print] PubMed PMID: 30742718.

The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients. Mikus M, Johansson C, Acevedo N, Nilsson P, Scheynius A. Clin Transl Allergy. 2019 Jan 31;9:6. doi: 10.1186/s13601-019-0240-4. eCollection 2019. PubMed PMID: 30728947; PubMed Central PMCID: PMC6354350.

Levels of horse allergen Equ C 4 in dander and saliva from ten horse breeds. Victor S, Binnmyr J, Lampa E, Rask-Andersen A, Elfman L. Clin Exp Allergy. 2019 Feb 4. doi: 10.1111/cea.13362. [Epub ahead of print] PubMed PMID: 30716182.

Epinephrine dispensings, allergy hospitalisations and the elimination of co-payments in Sweden. Protudjer JLP, Middelveld R, Ballardini N, Wai HM, Ahlstedt S, Nilsson L, Kivistö JE. Allergy. 2019 Jan 29. doi: 10.1111/all.13733. [Epub ahead of print] PubMed PMID: 30697761.

Maternal allergen-specific IgG may protect the child against allergic sensitization. Lupinek C, Hochwallner H, Johansson C, Mie A, Rigler E, Scheynius A, Alm J, Valenta R. J Allergy Clin Immunol. 2019 Jan 24. pii: S0091-6749(19)30106-X. doi: 10.1016/j.jaci.2018.11.051. [Epub ahead of print] PubMed PMID: 30685457.

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid. Morita H, Kubo T, Rückert B, Ravindran A, Soyka MB, Rinaldi AO, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O'Mahony L, Honda K, Nakae S, Saito H, Mjösberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA. J Allergy Clin Immunol. 2019 Jan 22. pii:S0091-6749(19)30088-0. doi: 10.1016/j.jaci.2018.12.1018. [Epub ahead of print]PubMed PMID: 30682454.

Dry skin and skin barrier in early infancy. Rehbinder EM, Winger AJ, Landrø L, Asarnoj A, Berents TL, Carlsen KH, Hedlin G, Jonassen CM, Nordlund B, Sandvik L, Skjerven HO, Söderhäll C, Vettukattil R, Carlsen KCL; study group. Br J Dermatol. 2019 Jan 13. doi: 10.1111/bjd.17626. [Epub ahead of print] PubMed PMID: 30637724.

Pediatric asthma: An unmet need for more effective, focused treatments.Papadopoulos NG, Čustović A, Cabana MD, Dell SD, Deschildre A, Hedlin G, Hossny E, Le Souëf P, Matricardi PM, Nieto A, Phipatanakul W, Pitrez PM, Pohunek P, Gavornikova M, Jaumont X, Price DB. Pediatr Allergy Immunol. 2019 Feb;30(1):7-16. doi: 10.1111/pai.12990. Epub 2018 Nov 15. Review. PubMed PMID: 30312503.

Treatable traits in the European U-BIOPRED adult asthma cohorts.Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Allergy. 2019 Feb;74(2):406-411. doi: 10.1111/all.13629. Epub 2018 Nov 12. PubMed PMID: 30307629.

Recommendations on Preschool Wheeze. Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments.Jartti T, Smits HH, Bønnelykke K, Bircan O, Elenius V, Konradsen JR, Maggina P, Makrinioti H, Stokholm J, Hedlin G, Papadopoulos N, Ruszczynski M, Ryczaj K, Schaub B, Schwarze J, Skevaki C, Stenberg-Hammar K, Feleszko W; EAACI Task Force on Clinical Practice. Allergy. 2019 Jan;74(1):40-52. doi: 10.1111/all.13624. Epub 2018 Nov 25. Review. PubMed PMID: 30276826.

Inflammatory response to dietary linoleic acid depends on FADS1 genotype. Lankinen MA, Fauland A, Shimizu BI, Ågren J, Wheelock CE, Laakso M, Schwab U, Pihlajamäki J. Am J Clin Nutr. 2019 Jan 1;109(1):165-175. doi: 10.1093/ajcn/nqy287. PubMed PMID: 30624587.

Upcoming conferences and meetings
in the asthma and allergy area

AAAAI Annual Meeting, 22-25 February 2019, San Francisco, USA

ERS Lung Science Conference "Mechanisms of acute exacerbation of respiratory disease", 7-10 March 2019, Estoril, Portugal

Lund Respiratory Network (LURN) Meeting "Inflammation in the lung", 21-22 March 2019, Ystad, Sweden

RHINA, European Rhinallergy Meeting, 21-23 March 2019, Eastbourne, United Kingdom

Konsul Th C Bergh's Foundation Scientific Symposium: Precision Medicine in Allergy and Asthma – New Possibilities?, 28 March 2019, Stockholm, Sweden

The Swedish Society for Allergology (SFFA) Annual Meeting, 2 April 2019, Aula Medica, KI

Swedish Lung Congress, 3-5 April 2019, Aula Medica, KI

SAM, Skin Allergy Meeting, 4-6 April 2019, Munich, Germany

ATS Annual Conference, 17-22 May 2019, Dallas, USA

EAACI Annual Congress, 1-5 June 2019, Lisbon, Portugal

9th meeting of the European Mast Cell and Basophil Research Network (EMBRN), 17-19 June 2019, Uppsala, Sweden

ERS International Congress, 28 September-2 October 2019, Madrid, Spain

EAACI PAAM (Pediatric Allergy and Asthma Meeting), 17-19 October 2019, Florence, Italy

16th International Conference "Bioactive Lipids in Cancer, Inflammation and Related Diseases", 20-23 October 2019, St. Petersburg, Florida, USA