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CfA news
The Centre for Allergy Research
Newsletter 4 April 2019
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15th April 2019: Anke-Hilse Maitland-van der Zee
Precision Medicine in respiratory disease, are we beyond fiction?
Speaker: Prof. Anke-Hilse Maitland-van der Zee, Professor of Precision Medicine in Respiratory Disease, Department of Respiratory Medicine and Department of Pediatric Respiratory Medicine, Amsterdam University Medical Centre, the Netherlands
Time: 16:00, 15th April 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Hosts: Bronwyn Haasdyk Brew, Dept. of Medical Epidemiology and Biostatistics, and Erik Melén, Institute of Environmental Medicine
Coffee and tea served 15:30
Welcome!
About the speaker:
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Anke-Hilse Maitland-
van der Zee
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Prof. Anke-Hilse Maitland-van der Zee was educated as a pharmacist, clinical pharmacologist and epidemiologist. She obtained her PhD at Utrecht University in 2003, and worked as a postdoc in the Human Genetics Center, University of Texas, Houston Tx, USA from 2003-2005. From 2005-2016 she worked at the division of Pharmacoepidemiology and Clinical Pharmacology of Utrecht University first as an assistant-Professor and later as an associate-Professor of Personalized Medicine.
In 2016, she became a full professor of Precision Medicine in Respiratory disease at the Academic Medical Center (AMC) in Amsterdam. She is also head of the research group at the Respiratory Medicine department and of the Pediatric Respiratory Medicine and Allergy department in the AMC.
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Her current research focusses on patient-, environmental characteristics and molecular biomarkers (genome, epigenome, transcriptome, microbiome, metabolome) that can predict the optimal treatment for the individual patient with respiratory disease. Maitland-van der Zee is the PI of several large (international) studies.
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A selection of Prof. Maitland-van der Zee's recent publications:
Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, S Oh S, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland van der Zee AH, Burchard EG, Pino-Yanes M. Clin Exp Allergy. 2019 Jan 29. doi: 10.1111/cea.13354. [Epub ahead of print]
17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use. Farzan N, Vijverberg SJ, Hernandez-Pacheco N, Bel EHD, Berce V, Bønnelykke K, Bisgaard H, Burchard EG, Canino G, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Forno E, Francis B, Hawcutt DB, Herrera-Luis E, Kabesch M, Karimi L, Melén E, Mukhopadhyay S, Merid SK, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Repnik K, Schieck M, Sevelsted A, Sio YY, Smyth RL, Soares P, Söderhäll C, Tantisira KG, Tavendale R, Tse SM, Turner S, Verhamme KM, Maitland-van der Zee AH. Allergy. 2018 Oct;73(10):2083-2088.
Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label.de Vries R, Dagelet YWF, Spoor P, Snoey E, Jak PMC, Brinkman P, Dijkers E, Bootsma SK, Elskamp F, de Jongh FHC, Haarman EG, In 't Veen JCCM, Maitland-van der Zee AH, Sterk PJ. Eur Respir J. 2018 Jan 11;51(1).
Biomarkers and asthma management: analysis and potential applications.Richards LB, Neerincx AH, van Bragt JJMH, Sterk PJ, Bel EHD, Maitland-van der Zee AH. Curr Opin Allergy Clin Immunol. 2018 Apr;18(2):96-108.
Early-life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis. Ahmadizar F, Vijverberg SJH, Arets HGM, de Boer A, Lang JE, Garssen J, Kraneveld A, Maitland-van der Zee AH. Allergy. 2018 May;73(5):971-986.
Breathomics from exhaled volatile organic compounds in pediatric asthma.Neerincx AH, Vijverberg SJH, Bos LDJ, Brinkman P, van der Schee MP, de Vries R, Sterk PJ, Maitland-van der Zee AH. Pediatr Pulmonol. 2017 Dec;52(12):1616-1627.
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Thank you, Göran Pershagen!
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On 21st February, Göran Pershagen held his senior lecture on the topic of "Environmental epidemiology - an intrument for the development of society through the decades". The lecture was organised by the Institute of Environmental Medicine to thank Göran Pershagen for his valuable contributions to environmental epidemiology research.
Some of the main scientific topics where he contributed substantially are health risk assessements of air pollutants, smoking, noise and radon. He was the initiator of the environmental health reports (miljöhälsorapporten), and was one of the initiators of the BAMSE cohort.
Göran Pershagen has been actively involved in the Centre for Allergy Research, and was a member of the CfA Steering Committee for many years.
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Thank you Göran Pershagen, for your valuable contributions to environmental and allergy research!
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From left to right: Craig Wheelock, Nikos Lazarinis, Sven-Erik Dahlén, Barbro Dahlén
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Nikolaos Lazarinis
Who successfully defended his thesis on 22nd February 2019.
Title: Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
Main supervisor: Barbro Dahlén, Co-supervisors: Sven-Erik Dahlén, Craig Wheelock
Opponent: Professor Brian Lipworth, University of Dundee, Scottish Centre for Respiratory Research, Division of Molecular and Clinical Medicine, United Kingdom
Link to Nikos Lazarinis' thesis
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Who successfully defended her thesis on 8th March 2019.
Title: Drug utilization in children with asthma – methodological approaches and practical implications
Main supervisor: Björn Wettermark, Co-supervisors: Inger Kull, Eva Wikström Jonsson, Catarina Almqvist Malmros
Opponent: Professor Eric van Ganse, Claude-Bernard Lyon1 University Pharmacoepidemiology / Health Services and Performance Research (HESPER); Croix Rousse University Hospital, Lyon, France Respiratory Medicine Patient Self-Management Training Unit, France
Link to Elin Dahlén's thesis
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Elin Dahlén, photo: Gunilla Sonnebring
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Avinash Ravindran
Who successfully defended his thesis on 15th March 2019.
Title: New insights on type 2 immunity key drivers: Mast cells and group 2 innate lymphoid cells
Main supervisor: Gunnar Nilsson, Co-supervisors: Jenny Mjösberg, Mikael Adner
Opponent: Associate Professor Madeleine Rådinger, University of Gothenburg, Department of Medicine, Division of Internal Medicine
Link to Avinash Ravindran's thesis
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Upcoming thesis defence in the
asthma and allergy area
26th April 2019: Maria Lagrelius
Institute of Environmental Medicine
Title: Contact allergy in Swedish adolescents: results from the BAMSE cohort study
Main supervisor: Carola Lidén, Co-supervisors: Anna Bergström, Carl-Fredrik Wahlgren, Inger Kull
Opponent: Professor Emeritus Chris Anderson Linköping University Department of Clinical and Experimental Medicine
Time: 9:00
Venue: Inghesalen, Widerströmska huset, Tomtebodavägen 18A, Solna
Link to Maria Lagrelius' thesis
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The "Good food for all" project had a successfull meeting with the target group - persons with food allergies and food hypersensitivity
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On Friday 29th March, KI and CfA hosted a meeting with the target group of the "Good food for all" (Bra mat för alla) project, persons with food allergies and hypersensitivity.
The purpose of the meeting was to inform about the national centre of excellence that is being built up, and to get input on the most pressing issues that persons with food hypersensitivity face in their daily lifes.
More about "Good food for all"
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The Good food for all project group, from left to right: Elisabet Rytter, Roelinde Middelveld, Emma Juslin, Sofia Knáz, Rikard Åsgård. Not in the picture: Mikaela Odemyr.
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Funding opportunity: Sanofi Genzyme announces
Type 2 Innovation Grant 2019
Sanofi Genzyme announces research grants to eight innovative projects designed to improve the lives of people with immune-mediated diseases (the “Type 2 Innovation Grant”).
Application deadline 31st May.
More information here
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Save the date: KiiM Retreat 3-4 October 2019
This year's KiiM retreat which will be held at Skogshem and Wijk on Lidingö 3-4 October. All the people involved in KiiM and Aii are currently working on the programme.
Are you a PhD student and want to help out?
Since this is an important and appreciated event for immunology doctoral students and usually there are around 70 students attending, doctoral students are encouraged to participate in the planning and organization! We are now looking for 2-3 doctoral students to join the KiiM 2019 organising committee!
This will be a great opportunity to network, gain experience of event planning, and make the 2019 KiiM retreat the best doctoral student retreat (+ it looks good on your CV).
Please contact one of the following persons if you are interested: caroline.gronwall@ki.se, stephen.malin@ki.se or mikael.karlsson@ki.se
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Recent publications by CfA researchers
A Multicenter, Observational, Prospective Study of the Effectiveness of Switching from Budesonide/Formoterol Turbuhaler® to Budesonide/Formoterol Easyhaler®. Syk J, Vinge I, Sörberg M, Vahteristo M, Rytilä P. Adv Ther. 2019 Apr 2. doi: 10.1007/s12325-019-00940-7. [Epub ahead of print]
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. Ferreira MAR, Mathur R, Vonk JM, Szwajda A, Brumpton B, Granell R, Brew BK, Ullemar V, Lu Y, Jiang Y; 23andMe Research Team; eQTLGen Consortium; BIOS Consortium, Magnusson PKE, Karlsson R, Hinds DA, Paternoster L, Koppelman GH, Almqvist C. Am J Hum Genet. 2019 Mar 27. pii: S0002-9297(19)30067-9. doi: 10.1016/j.ajhg.2019.02.022. [Epub ahead of print]
Stratification of asthma phenotypes by airway proteomic signatures. Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group. J Allergy Clin Immunol. 2019 Mar 27. pii: S0091-6749(19)30415-4. doi: 10.1016/j.jaci.2019.03.013. [Epub ahead of print]
Nocturnal asthma is affected by genetic interactions between RORA and NPSR1. Gaertner VD, Michel S, Curtin JA, Pulkkinen V, Acevedo N, Söderhäll C, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Pershagen G, Melén E, Simpson A, Custovic A, Kere J, Kabesch M. Pediatr Pulmonol. 2019 Mar 29. doi: 10.1002/ppul.24292. [Epub ahead of print]
Alpha-gal phenotypes- lessons from various patient populations. Levin M, Apostolovic D, Biedermann T, Commins SP, Iweala OI, Platts-Mills TAE, Savi E, van Hage M, Wilson JM. Ann Allergy Asthma Immunol. 2019 Mar 25. pii: S1081-1206(19)30200-5. doi: 10.1016/j.anai.2019.03.021. [Epub ahead of print] Review.
Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells. Hochdörfer T, Winkler C, Pardali K, Mjösberg J. Eur J Immunol. 2019 Mar 20. doi: 10.1002/eji.201848006. [Epub ahead of print]
Allergens in dog extracts: implication for diagnosis and treatment. Wintersand A, Asplund K, Binnmyr J, Holmgren E, Nilsson OB, Gafvelin G, Grönlund H. Allergy. 2019 Mar 19. doi: 10.1111/all.13785. [Epub ahead of print]
Prescribed analgesics in pregnancy and risk of childhood asthma. Shaheen SO, Lundholm C, Brew BK, Almqvist C. Eur Respir J. 2019 Mar 17. pii: 1801090. doi: 10.1183/13993003.01090-2018. [Epub ahead of print]
Alcohol Consumption and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men. Kaluza J, Harris HR, Linden A, Wolk A. Am J Epidemiol. 2019 Mar 16. pii: kwz020. doi: 10.1093/aje/kwz020. [Epub ahead of print]
Immune Cell-Derived Extracellular Vesicles - Functions and Therapeutic Applications. Veerman RE, Güçlüler Akpinar G, Eldh M, Gabrielsson S. Trends Mol Med. 2019 Mar 7. pii: S1471-4914(19)30035-8. doi: 10.1016/j.molmed.2019.02.003. [Epub ahead of print] Review.
Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption. Acevedo N, Frumento P, Harb H, Alashkar Alhamwe B, Johansson C, Eick L, Alm J, Renz H, Scheynius A, Potaczek DP. Int J Mol Sci. 2019 Mar 1;20(5). pii: E1060. doi: 10.3390/ijms20051060.
Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children. Huoman J, Papapavlou G, Pap A, Alm J, Nilsson LJ, Jenmalm MC. Pediatr Allergy Immunol. 2019 Feb 25. doi: 10.1111/pai.13047. [Epub ahead of print]
Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents. Jiang Y, Gruzieva O, Wang T, Forno E, Boutaoui N, Sun T, Merid SK, Acosta-Pérez E, Kull I, Canino G, Antó JM, Bousquet J, Melén E, Chen W, Celedón JC. Eur Respir J. 2019 Mar 28. pii: 1900102. doi: 10.1183/13993003.00102-2019. [Epub ahead of print]
Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping. Gomez C, Gonzalez-Riano C, Barbas C, Kolmert J, Hyung Ryu M, Carlsten C, Dahlen SE, Wheelock CE. J Lipid Res. 2019 Mar 6. pii: jlr.D090571. doi: 10.1194/jlr.D090571. [Epub ahead of print]
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Upcoming conferences and meetings
in the asthma and allergy area
Swedish Lung Congress, 3-5 April 2019, Aula Medica, KI
SAM, Skin Allergy Meeting, 4-6 April 2019, Munich, Germany
ATS Annual Conference, 17-22 May 2019, Dallas, USA
EAACI Annual Congress, 1-5 June 2019, Lisbon, Portugal
9th meeting of the European Mast Cell and Basophil Research Network (EMBRN), 17-19 June 2019, Uppsala, Sweden
ERS International Congress, 28 September-2 October 2019, Madrid, Spain
EAACI PAAM (Pediatric Allergy and Asthma Meeting), 17-19 October 2019, Florence, Italy
16th International Conference "Bioactive Lipids in Cancer, Inflammation and Related Diseases", 20-23 October 2019, St. Petersburg, Florida, USA
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About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy. ki.se/cfa
How we treat your personal data
Read about how we treat your personal data at CfA's website. If you do not wish to receive the newsletter any longer, please click "unsubscribe" at the top of this newsletter. If you wish to subsribe to this newsletter, please contact Roelinde.Middelveld@ki.se. By doing so, you consent to treatment of your personal data as described here.
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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Roelinde Middelveld
kontakt: ki.se/cfa e-mail: cfa@imm.ki.se
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