Have a great and relaxing summer!

We will be back in August.
 

Sunset at the Baltic Sea. Photo: Roelinde Middelveld

Asthma still kills -

New report from Asthma UK and Academia Europaea

A new report, Asthma still kills, from Asthma UK and Academia Europaea – an official advisor to the European Commission – has recently been published. The report seeks to identify urgent priorities for the international research community to treat, prevent and cure asthma.

Asthma still kills summarises a meeting of global asthma experts held in late 2018 and aims to provide direction for where research into asthma mechanisms needs to go next, highlighting the unmet need for further research into non-T2 (non-eosinophilic) asthma.

Studies have shown that up to 50% of people with asthma respond poorly to conventional anti-inflammatory or anti-eosinophil treatments, yet research into non-T2 asthma remains limited. The report identifies four key areas for urgent research: the role of sex hormones, the microbiome, the impact of airway nerves and air pollution. Additionally, experts identified a need for further investigation into those with severe asthma who do not respond to steroid treatment and the possibility of primary prevention in children.

Read more at Asthma UK's website

Upcoming CfA seminars

3rd October 2019: Vanessa Murphy

Topic: Asthma in pregnancy
Speaker: Dr. Vanessa Murphy, University of Newcastle, Australia

Time: 16:00, 3rd October 2019
Venue: Biomedicum Lecture Hall 3 (A0325), Entrance Level, Solnavägen 9, KI Campus Solna
Hosts: Bronwyn Haasdyk Brew and Catarina Almqvist Malmros, Dept. of Medical Epidemiology and Biostatistics
Coffee and tea served 15:30

Registration to the KiiM retreat is open

This year's KiiM retreat will be at Skogshem & Wijk on the 3rd and 4th of October

The following speakers are confirmed:

The number of attendees is limited to 170 this year, but once again the meeting is free of charge. There will be a large number of short talks selected based on submitted abstracts. All attendees are encouraged to submit an abstract to be eligible for oral presentation. Students and postdocs are required to submit an abstract, as this will be the most important criteria for admission to the meeting. Registration closes on August 12th or when the maximum number of qualified registrations has been reached.
Send any questions to: anna.smed.sorensen@ki.se.

Link to registration to the KiiM retreat

Spirometry course - theory and practice

The Department of Clinical Science and Education, Södersjukhuset, will organise a course on spirometry this autumn, aimed at health care professionals such as nurses, physicians and physiotherapists. The course will be a hands-on course including both theory and practice. Registration deadline: 1st August.

Contact person: Inger.Kull@ki.se

More information available here

Aii grants available for the organisation

of workshops and minisymposia 

in the area of

Allergy, immunology and inflammation

The doctoral programme Aii (Allergy, immunology and inflammation) announces GRANTS available for the organization of workshops and minisymposia in the area of Allergy, immunology and inflammation

Please contact Caroline Grönwall, chair of the Aii program, or Jan Wahlström, program coordinator, for more information about requirements and how you can apply.

Costs that may be covered include travel and accommodation for invited speakers, rent of venue, lunches and coffee breaks etc.

Recent publications by CfA researchers
 

Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection. Säfholm J, Manson ML, Bood J, Al-Ameri M, Orre AC, Raud J, Dahlén SE, Adner M. J Allergy Clin Immunol. 2019 Jun 14. pii: S0091-6749(19)30763-8.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux. Perotin JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group; U-BIOPRED:. Eur Respir J. 2019 Jun 27;53(6). pii: 1900453.

Epinephrine dispensings, allergy hospitalizations and the elimination of co-payments in Sweden. Protudjer JLP, Middelveld R, Ballardini N, Wai HM, Ahlstedt S, Nilsson L, Kivistö JE. Allergy. 2019 Jun;74(6):1197-1200.

Sibship and dispensing patterns of asthma medication in young children-a population-based study. Dahlén E, Ekberg S, Lundholm C, Jonsson EW, Kull I, Wettermark B, Almqvist C. Pharmacoepidemiol Drug Saf. 2019 Jul 4.

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells. Tibbitt CA, Stark JM, Martens L, Ma J, Mold JE, Deswarte K, Oliynyk G, Feng X, Lambrecht BN, De Bleser P, Nylén S, Hammad H, Arsenian Henriksson M, Saeys Y, Coquet JM. Immunity. 2019 Jun 14. pii: S1074-7613(19)30234-1.

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens. Huang HJ, Curin M, Banerjee S, Chen KW, Garmatiuk T, Resch-Marat Y, Carvalho-Queiroz C, Blatt K, Gafvelin G, Grönlund H, Valent P, Campana R, Focke-Tejkl M, Valenta R, Vrtala S. Allergy. 2019 Jun 22.

Bronchodilator reversibility in asthma and COPD: Findings from three large population studies. Janson C, Malinovschi A, Amaral AFS, Accordini S, Bousquet J, Sonia Buist A, Canonica GW, Dahlén B, Garcia-Aymerich J, Gnatiuc L, Kowalski ML, Patel J, Tan W, Torén K, Zuberbier T, Burney P, Jarvis D. Eur Respir J. 2019 Jun 20. pii: 1900561. doi: 10.1183/13993003.00561-2019. [Epub ahead of print]

The allergic phenotype during the first 10 years of life in a prospective cohort. Björkander S, Hallberg J, Persson JO, Lilja G, Nilsson C, Sverremark-Ekström E. Immun Inflamm Dis. 2019 Jun 17.

Living with a severe allergy: Lived perspectives from Swedish adolescents and their parents. Lagercrantz B, Persson Å, Jonsson M, Kull I. J Pediatr Nurs. 2019 Jun 10. pii: S0882-5963(18)30581-5.

Vaccination and Allergic Sensitization in Early Childhood - The ALADDIN Birth Cohort. Swartz J, Aronsson B, Lindblad F, Järnbert-Pettersson H, Scheynius A, Pershagen G, Alm J. EClinicalMedicine. 2018 Nov 6;4-5:92-98. doi: 10.1016/j.eclinm.2018.10.005. eCollection 2018 Oct-Nov

Effect of Spironolactone for One Year on Endothelial Function and Vascular Inflammation Biomarkers in Renal Transplant Recipients. Mortensen LA, Bistrup C, Stubbe J, Carlström M, Checa A, Wheelock CE, Palarasah Y, Bladbjerg EM, Thiesson HC, Jensen BL. Am J Physiol Renal Physiol. 2019 Jun 5.

Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells. Scharenberg M, Vangeti S, Kekäläinen E, Bergman P, Al-Ameri M, Johansson N, Sondén K, Falck-Jones S, Färnert A, Ljunggren HG, Michaëlsson J, Smed-Sörensen A, Marquardt N. Front Immunol. 2019 May 17;10:1116. doi: 10.3389/fimmu.2019.01116. eCollection 2019.

Genetic risk scores do not improve asthma prediction in childhood. Dijk FN, Folkersma C, Gruzieva O, Kumar A, Wijga AH, Gehring U, Kull I, Postma DS, Vonk JM, Melén E, Koppelman GH. J Allergy Clin Immunol. 2019 May 27. pii: S0091-6749(19)30687-6. doi: 10.1016/j.jaci.2019.05.017. [Epub ahead of print] No abstract available.

Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma. Um-Bergström P, Hallberg J, Pourbazargan M, Berggren-Broström E, Ferrara G, Eriksson MJ, Nyrén S, Gao J, Lilja G, Lindén A, Wheelock ÅM, Melén E, Sköld CM. Respir Res. 2019 May 24;20(1):102. doi: 10.1186/s12931-019-1075-1.

Subsetting reveals CD16high CD62Ldim neutrophils in chronic rhinosinusitis with nasal polyps. Arebro J, Drakskog C, Winqvist O, Bachert C, Kumlien Georén S, Cardell LO. Allergy. 2019 May 22.

Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells. McGovern TK, Farahnak S, Chen M, Larsson K, Martin JG, Adner M. Am J Physiol Lung Cell Mol Physiol. 2019 May 22.

Epigenetic Modifications in Placenta are Associated with the Child's Sensitization to Allergens. Harb H, Alashkar Alhamwe B, Acevedo N, Frumento P, Johansson C, Eick L, Papadogiannakis N, Alm J, Renz H, Potaczek DP, Scheynius A. Biomed Res Int. 2019 Apr 17;2019:1315257. doi: 10.1155/2019/1315257. eCollection 2019.

Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model. Kooter I, Ilves M, Gröllers-Mulderij M, Duistermaat E, Tromp PC, Kuper F, Kinaret P, Savolainen K, Greco D, Karisola P, Ndika J, Alenius H. ACS Nano. 2019 Jun 25;13(6):6932-6946. doi: 10.1021/acsnano.9b01823. Epub 2019 Jun 17.

Eliminated patient fee and changes in dispensing patterns of asthma medication in children-An interrupted time series analysis. Dahlén E, Komen J, Jonsson EW, Almqvist C, Kull I, Wettermark B. Basic Clin Pharmacol Toxicol. 2019 Jun 12.

DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics. Wang AL, Gruzieva O, Qiu W, Merid SK, Celedón JC, Raby BA, Söderhäll C, DeMeo DL, Weiss ST, Melén E, Tantisira KG. Clin Exp Allergy. 2019 Jun 12.

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis. Gruzieva O, Xu CJ, Yousefi P, Relton C, Merid SK, Breton CV, Gao L, Volk HE, Feinberg JI, Ladd-Acosta C, Bakulski K, Auffray C, Lemonnier N, Plusquin M, Ghantous A, Herceg Z, Nawrot TS, Pizzi C, Richiardi L, Rusconi F, Vineis P, Kogevinas M, Felix JF, Duijts L, den Dekker HT, Jaddoe VWV, Ruiz JL, Bustamante M, Antó JM, Sunyer J, Vrijheid M, Gutzkow KB, Grazuleviciene R, Hernandez-Ferrer C, Annesi-Maesano I, Lepeule J, Bousquet J, Bergström A, Kull I, Söderhäll C, Kere J, Gehring U, Brunekreef B, Just AC, Wright RJ, Peng C, Gold DR, Kloog I, DeMeo DL, Pershagen G, Koppelman GH, London SJ, Baccarelli AA, Melén E. Environ Health Perspect. 2019 May;127(5):57012. doi: 10.1289/EHP4522. Epub 2019 May 31.

Nursing care and management of patients' sleep during hospitalisation: A cross-sectional study. Gellerstedt L, Medin J, Kumlin M, Rydell Karlsson M. J Clin Nurs. 2019 May 15.

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. Bergqvist F, Ossipova E, Idborg H, Raouf J, Checa A, Englund K, Englund P, Khoonsari PE, Kultima K, Wheelock CE, Larsson K, Korotkova M, Jakobsson PJ. Front Pharmacol. 2019 Jun 7;10:636. doi: 10.3389/fphar.2019.00636. eCollection 2019.

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. Chu SH, Huang M, Kelly RS, Benedetti E, Siddiqui JK, Zeleznik OA, Pereira A, Herrington D, Wheelock CE, Krumsiek J, McGeachie M, Moore SC, Kraft P, Mathé E, Lasky-Su J; Consortium of Metabolomics Studies Statistics Working Group. Metabolites. 2019 Jun 18;9(6).

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium. Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE. Metabolites. 2019 Jun 6;9(6).

Upcoming conferences and meetings
in the asthma and allergy area

ERS International Congress, 28 September-2 October 2019, Madrid, Spain

EAACI PAAM (Pediatric Allergy and Asthma Meeting), 17-19 October 2019, Florence, Italy

16th International Conference "Bioactive Lipids in Cancer, Inflammation and Related Diseases", 20-23 October 2019, St. Petersburg, Florida, USA

ERS Research Seminar "Early Origins of Lung Disease: an interdisciplinary approach", 11-12 November 2019, Lisbon, Portugal

EAACI ISMA (International Symposium on Molecular Allergology), 28-30 November 2019, Amsterdam, the Netherlands

EAACI Allergy School on Food Allergy, 5 - 7 December 2019, Paris, France

EAACI Winter School 2020 Basic Immunology Research in Allergy and Clinical Immunology, 23 - 26 January 2020, Chamonix, France

ERS Satellite Symposium, 20 February 2019:
COPD - Prevention of exacerbations and new treatment pathways in COPD
ASTHMA - Prevention of exacerbations and oral steroid use in Asthma

ERS Lung Science Conference - Metabolic alterations in lung ageing and disease, 5-8 March 2020, Estoril, Portugal

AAAAI Annual Meeting, 13-16 March 2020, Philadelphia, USA

ATS International Conference, 15-20 May 2019, Philadelphia, USA