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The Centre for Allergy Research

Newsletter 21 Oct 2019


Upcoming CfA seminars

6th November 2019: Jennifer Protudjer

Food allergy: Issues beyond avoidance

Speaker: Dr. Jennifer Protudjer, Department of Pediatrics and Child Health, The University of Manitoba, Winnipeg, Canada.

Time: 16:00, 6th November 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 15:30


About the speaker:

Dr. Jennifer Protudjer is an Assistant Professor, in the Department of Pediatrics and Child Health, at the University of Manitoba, and holds an affiliation to the Institute of Environmental Medicine, Karolinska Institutet. She is on many committees within the American Academy of Asthma, Allergy and Immunology.

She also sits on the steering committees for Food Allergy Canada’s National Food Allergy Action Plan and Sweden’s Bra mat för Alla [Good Food for All]. She completed her post-doctoral training at Karolinska Institutet, where she led FoodHE II, the Food Allergy Health Economics Group, Part II.

Dr. Jennifer Protudjer

Dr. Protudjer’s current research focus is on the environmental risk factors for, and societal consequences of allergic diseases, which she investigates using mixed methods, thereby focusing on the impact of allergic diseases on child growth and pubertal development and financial and mental health. She has expertise in mixed methods, food allergy, health economics, quality of life, knowledge translation and nutrition.


7th November 2019: Bart Lambrecht

The solution of a 150 year old riddle discovers a new mechanism to resolve eosinophilic inflammation

Speaker: Prof. Bart Lambrecht, Laboratory of Mucosal Immunology and Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium.


Time: 15:00, 7th November 2019
Venue: Biomedicum Lecture Hall 4 (A0315), Entrance Level, Solnavägen 9, KI Campus Solna
Host: Sven-Erik Dahlén, Institute of Environmental Medicine
Coffee and tea served 14:30


About the speaker:

Research in Prof. Lambrecht's group is focused on unraveling the functions of lung dendritic cells and epithelial cells in asthma and respiratory viral infection. Asthma is a chronic inflammatory disease of the airways characterized by eosinophilic airway inflammation, goblet cell metaplasia and bronchial hyperreactivity. A frequent cause of exacerbations is respiratory viral infection. There is an epidemic of asthma in the Western world, of which the cause in unclear, and for which novel forms of prevention and treatment are urgently needed. In allergic asthma, allergen-specific Th2 lymphocytes cause inflammation, as well as formation of allergen specific IgE, also known as allergic sensitization.

Prof. Bart Lambrecht

In the past years, Prof. Lambrecht's lab has found crucial roles for antigen presenting dendritic cells (DCs) in causing allergic sensitization. They have shown that DCs also play a crucial role also in maintenance of chronic airway inflammation.


Congratulations Sven-Erik Dahlén!

Sven-Erik Dahlén, Director of CfA and Professor at the Institute of Environmental Medicine, was awarded the

Eicosanoid Research Foundation’s Exceptional Contributions to Human Physiology and Translational Medicine Award

The award will be handed out at the 16th International Bioactive Lipids Conference, currently taking place in St. Petersburg, Florida

More about the award

Prof. Sven-Erik Dahlén


National Tolerance Conference organised by

the Asthma and Allergy Association in

Stockholm 5-7 February 2020


On 5-7 February 2020 the Swedish Asthma and Allergy Association, together with the Asthma and Allergy Association's Research Foundation, will organise a National Tolerance Conference. The conference will be organised in collaboration with professional health care organisations, and the aim is to dissiminate the latest knowledge around the development of tolerance in allergic disease and to create more interest for allergic diseases in society in general.

The main purpose will be to present the latest findings on tolerance induction and how to avoid allergic disease. The conference invites experts, scientists, policymakers, decision-makers, as well as members of the Asthma and Allergy Association, to participate.

With this conference, the Asthma and Allergy Assocation has a further goal to inspire policymakers and authorities to take the initiative for a broad national strategy to improve the quality of life of those with allergic diseases.

Preliminary programme and registration:


Funding opportunity - The Chan Zuckerberg Initiative

The Chan Zuckerberg Initiative (CZI) invites applications for two-year collaborative pilot projects focused on the role of inflammation in maintaining health and triggering disease. CZI will accept applications from teams of two to three researchers with distinct expertise.

More information available here

Application deadline: 19th November 2019


Upcoming thesis defenses at KI in the

asthma and allergy area

29th November: Sandra Ekstedt
Department of Clinical Science, Intervention and Technology

Title: Neutrophil subsets in airway inflammation and hyperreactivity

Main supervisor: Lars Olaf Cardell, Co-supervisor: Susanna Kumlien Georén

Opponent: Associate Professor Madeleine Rådinger, Dept. of Medicine, Gothenburg University

Time: 9:00
Venue: Lars Leksell Lecture Hall, Karolinska University Hospital, NKS, Solna


Upcoming seminars at KI in the

asthma and allergy area


12th November: Allergi mot mat - kan det vara farligt?
Speaker: Caroline Nilsson, Dept. of Clinical Science and Education, Södersjukhuset

Time: 17:30
Venue: Södersjukhuset, Aulan (hiss C, plan 6)

More information on KI's calender (in Swedish)


14th November: Bli inspirerad av en professor - Erik Melén
Speaker: Erik Melén, Dept. of Clinical Science and Education, Södersjukhuset

Time: 12:15
Venue: Campus Flemingsberg, Entrén Universitetsbiblioteket, Alfred Nobels Allé 8

More information on KI's calender (in Swedish)
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2nd December: Immunology and Microbiology seminar "Tissue-specific features of human innate lymphoid cells"
Speaker: Jenny Mjösberg, Centre for Infectious Medicine

Time: 13:00
Venue: Biomedicum room D1012, Biomedicum floor 10, Solnavägen 9

More information on KI's calender


11th December: CIM Seminar “Tissue-specific features of human lung NK cell subsets in health and disease”
Speaker: Nicole Marquardt, Centre for Infectious Medicine

Time: 14:00
Venue: Campus Flemingsberg, ANA Futura, von Behring room, Floor 9

More information on KI's calendar


Recent publications by CfA researchers


Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection. Säfholm J, Manson ML, Bood J, Al-Ameri M, Orre AC, Raud J, Dahlén SE, Adner M. J Allergy Clin Immunol. 2019 Oct;144(4):984-992. doi: 10.1016/j.jaci.2019.04.031. Epub 2019 Jun 14.

Characteristics and treatment regimens across ERS SHARP severe asthma registries. van Bragt JJMH, Adcock IM, Bel EHD, Braunstahl GJ, Ten Brinke A, Busby J, Canonica GW, Cao H, Chung KF, Csoma Z, Dahlen B, Davin E, Hansen S, Heffler E, Horvath I, Korn S, Kots M, Kuna P, Kwon N, Louis R, Plaza V, Porsbjerg C, Ramos-Barbon D, Richards LB, Skrgat S, Sont JK, Vijverberg SJH, Weersink EJ, Yasinska V, Wagers SS, Djukanovic R, Maitland-van der Zee AH; SHARP CRC. Eur Respir J. 2019 Oct 10. pii: 1901163. doi: 10.1183/13993003.01163-2019. [Epub ahead of print]

Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD. Naz S, Bhat M, Ståhl S, Forsslund H, Sköld CM, Wheelock ÅM, Wheelock CE. Metabolites. 2019 Oct 1;9(10). pii: E212. doi: 10.3390/metabo9100212.

Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium. Hallgren J, Hellman L, Maurer M, Nilsson GP, Wernersson S, Åbrink M, Pejler G. Allergy. 2019 Sep 26. doi: 10.1111/all.14065. [Epub ahead of print] No abstract available.

Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts. Che KF, Sun J, Linden A. Front Pharmacol. 2019 Aug 30;10:956. doi: 10.3389/fphar.2019.00956. eCollection 2019.

Maternal food allergy is associated with daughters' menarche in early adolescence. Protudjer JLP, Abrams EM, Kozyrskyj AL, Becker AB. Allergy Asthma Clin Immunol. 2019 Sep 11;15:57. doi: 10.1186/s13223-019-0371-0. eCollection 2019.

Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma. Brinkman P, Ahmed WM, Gómez C, Knobel HH, Weda H, Vink TJ, Nijsen TM, Wheelock CE, Dahlen SE, Montuschi P, Knowles RG, Vijverberg SJ, Maitland-van der Zee AH, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Eur Respir J. 2019 Sep 12. pii: 1900544. doi: 10.1183/13993003.00544-2019. [Epub ahead of print]

Maternal anxiety, depression and asthma and adverse pregnancy outcomes - a population based study. Rejnö G, Lundholm C, Öberg S, Lichtenstein P, Larsson H, D'Onofrio B, Larsson K, Saltvedt S, Brew BK, Almqvist C. Sci Rep. 2019 Sep 11;9(1):13101. doi: 10.1038/s41598-019-49508-z.

Food allergy-related concerns during the transition to self-management. Protudjer JLP, Middelveld R, Dahlén SE, Ahlstedt S; FoodHE Investigators. Allergy Asthma Clin Immunol. 2019 Sep 5;15:54. doi: 10.1186/s13223-019-0370-1. eCollection 2019.

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma. George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, Boschetto P, Parr DG, Nowinski A, Barta I, Hohlfeld J, Greulich T, van den Berge M, Hiemstra PS, Timens W, Hinks T, Wenzel S, Siddiqui S, Richardson M, Venge P, Heath S, Gut I, Tobin MD, Edwards L, Riley JH, Djukanovic R, Auffray C, De-Meulder B, Erik-Dahlen S, Adcock IM, Chung KF, Ziegler-Heitbrock L, Sterk PJ, Singh D, Brightling CE; U-BIOPRED and the EvA study teams. Allergy. 2019 Sep 10. doi: 10.1111/all.14016. [Epub ahead of print]

Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma. Kere M, Gruzieva O, Ullemar V, Söderhäll C, Greco D, Kull I, Bergström A, Pershagen G, Almqvist C, Melén E. Allergy. 2019 Sep 9. doi: 10.1111/all.14043. [Epub ahead of print] No abstract available.

Human papillomavirus and infiltration of CD8- and Foxp3-positive immune cells in sinonasal inverted papillomas. Elliot A, Näsman A, Westman M, Marklund L, Stjärne P, Hammarstedt-Nordenvall L. Acta Otolaryngol. 2019 Nov;139(11):1019-1023. doi: 10.1080/00016489.2019.1654616. Epub 2019 Sep 5.

Clinical effect on uncontrolled asthma using a novel digital automated self-management solution: a physician-blinded randomised controlled crossover trial. Ljungberg H, Carleborg A, Gerber H, Öfverström C, Wolodarski J, Menshi F, Engdahl M, Eduards M, Nordlund B. Eur Respir J. 2019 Sep 3. pii: 1900983. doi: 10.1183/13993003.00983-2019. [Epub ahead of print]

Acute wheeze-specific gene module shows correlation with vitamin D and asthma medication. Katayama S, Hammar KS, Krjutškov K, Einarsdottir E, Hedlin G, Kere J, Söderhäll C. Eur Respir J. 2019 Oct 16. pii: 1901330. doi: 10.1183/13993003.01330-2019. [Epub ahead of print]

Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells. McGovern T, Farahnak S, Chen M, Larsson K, Martin JG, Adner M. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L305-L316. doi: 10.1152/ajplung.00377.2018. Epub 2019 May 22.

Metabolomic Analysis of Yeast and Human Cells: Latest Advances and Challenges. Chaleckis R, Ohashi K, Meister I, Naz S, Wheelock CE. Methods Mol Biol. 2019;2049:233-245. doi: 10.1007/978-1-4939-9736-7_14.

Predicting Skin Barrier Dysfunction and Atopic Dermatitis in Early Infancy. Rehbinder EM, Advocaat Endre KM, Lødrup Carlsen KC, Asarnoj A, Stensby Bains KE, Berents TL, Carlsen KH, Gudmundsdóttir HK, Haugen G, Hedlin G, Kreyberg I, Nordhagen LS, Nordlund B, Saunders CM, Sandvik L, Skjerven HO, Söderhäll C, Staff AC, Vettukattil R, Værnesbranden MR, Landrø L; study group, Carlsen MH, Lødrup Carlsen OC, Granlund PA, Granum B, Götberg S, Hilde K, Jonassen CM, Nygaard UC, Rudi K, Skrindo I, Sjøborg K, Tedner SG, Wiik J, Winger AJ. J Allergy Clin Immunol Pract. 2019 Sep 27. pii: S2213-2198(19)30792-5. doi: 10.1016/j.jaip.2019.09.014. [Epub ahead of print]


Upcoming conferences and meetings
in the asthma and allergy area


16th International Conference "Bioactive Lipids in Cancer, Inflammation and Related Diseases", 20-23 October 2019, St. Petersburg, Florida, USA

ERS Research Seminar "Early Origins of Lung Disease: an interdisciplinary approach", 11-12 November 2019, Lisbon, Portugal

Nordic Allergology Meeting, 20-22 November 2019, Oslo, Norway

EAACI ISMA (International Symposium on Molecular Allergology), 28-30 November 2019, Amsterdam, the Netherlands

EAACI Allergy School on Food Allergy, 5 - 7 December 2019, Paris, France

EAACI Winter School 2020 Basic Immunology Research in Allergy and Clinical Immunology, 23 - 26 January 2020, Chamonix, France

Tolerance Conference, organised by the Swedish Asthma and Allergy Association, 5-7 February 2020, Stockholm, Sweden

19th Fraunhofer Seminar "Models of Lung Disease", 6-7 February 2020, Hannover, Germany

ERS Satellite Symposium, 20 February 2019:
COPD - Prevention of exacerbations and new treatment pathways in COPD
ASTHMA - Prevention of exacerbations and oral steroid use in Asthma

ERS Lung Science Conference - Metabolic alterations in lung ageing and disease, 5-8 March 2020, Estoril, Portugal

AAAAI Annual Meeting, 13-16 March 2020, Philadelphia, USA

ATS International Conference, 15-20 May 2019, Philadelphia, USA


About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy.

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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Roelinde Middelveld
kontakt: e-mail:

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