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The Centre for Allergy Research

Newsletter 14 Sep 2020

Welcome back after the summer break!


Highlights from the European Respiratory Society 2020

This years virtual ERS event has just finished, although it is still possible to access much of the pre-recorded content. If you registered you can access material until 30th December 2020. A selection of highlights from KI scientists of particular relevance to allergic airway disease are described below.

Cecilia Lundholm and Björn Lundberg revealed how early-life exposures to inhaled allergens or air pollution can affect later lung function.

Descriptions of biomarker patterns associated with asthma phenotypes were provided by Maria Mikus, Lars Andersson, Valentyna Yasinska and Anna James.

Novel insights into mechanisms of allergic asthma using experimental models were provided by Jielu Liu and Jesper Säfholm.

A detailed overview of the involvement and importance of upper airways in lower airway disease was given by Apostolos Bossios.


Forthcoming half-time seminars


Valentyna Yasinska

Online meeting, link to follow, 13th October at 14.00

Department of Medicine, H7

Title: New non-invasive biomarkers for clinical phenotyping of asthma and other respiratory diseases

Main supervisor: Barbro Dahlén

Co-supervisors: Sven-Erik Dahlén, Craig Wheelock and Apostolos Bossios

Valentyna Yasinska

Jielu Liu

Jielu Liu

Online meeting, link to follow, 28th October at 13:00

Institute of Environmental Medicine

Title: Defining the role of mast cells in allergic asthma using guinea pig as animal models

Main supervisor: Mikael Adner

Co-supervisors: Gunnar Nilsson, Sven-Erik Dahlén and Jesper Säfholm


COVID-19 research


Erik Melén and collegues from the BAMSE study will be investigating the long-term effects of COVID-19 infection in young adults, focusing on the immune system and lung function. To read more about this work see the recent article in Svenska Dagbladet.



Funding opportunities


The L’Oréal-Unesco For Women in Science Sweden Prize with support of The Young Academy of Sweden, deadline 26 September

Cancer och allergifonden, research grant, deadline 30 September

Asthma och allergiförbundet, research grant, deadline 30 September


Recent publications by CfA researchers


The CfA congratulates Johan Kolmert and collegues on their important publication in the blue journal, regarding the use of urinary eicosanoids to identify patients with a particular phenotype of asthma driven by eosinophilic inflammation. There is also an editorial to accompany written by Stokes Peebles, see below. Well done Johan!

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group. Am J Respir Crit Care Med. 2020 Jul 15. doi: 10.1164/rccm.201909-1869OC. Online ahead of print. PMID: 32667261

Urine - A Lens for Asthma Pathogenesis and Treatment? Peebles RS Jr.Am J Respir Crit Care Med. 2020 Aug 13. doi: 10.1164/rccm.202007-2899ED. Online ahead of print.PMID: 32791002 No abstract available

Associations between food allergy and perceived life status. Middelveld R, Gunnarsson NV, Ahlstedt S, Protudjer JLP.Ann Allergy Asthma Immunol. 2020 Jul 24:S1081-1206(20)30513-5. doi: 10.1016/j.anai.2020.07.021. Online ahead of print.PMID: 32717299

eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy. Abdel-Aziz MI, Brinkman P, Vijverberg SJH, Neerincx AH, de Vries R, Dagelet YWF, Riley JH, Hashimoto S, Chung KF, Djukanovic R, Fleming LJ, Murray CS, Frey U, Bush A, Singer F, Hedlin G, Roberts G, Dahlén SE, Adcock IM, Fowler SJ, Knipping K, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH; U-BIOPRED Study Group; Amsterdam UMC Breath Research Group. J Allergy Clin Immunol. 2020 Jun 10:S0091-6749(20)30808-3. doi: 10.1016/j.jaci.2020.05.038. Online ahead of print. PMID: 32531371

A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig. Ramos-Ramírez P, Noreby M, Liu J, Ji J, Abdillahi SM, Olsson H, Dahlén SE, Nilsson G, Adner M. Clin Exp Allergy. 2020 Jul 21. doi: 10.1111/cea.13713. Online ahead of print. PMID: 32691918

YKL-40 is a proposed biomarker of inflammation and remodelling elevated in children with bronchopulmonary dysplasia compared to asthma. James AJ, Nordlund B, Konradsen JR, Ebersjö C, Dahlén SE, Berggren Broström E, Hedlin G. Acta Paediatr. 2020 Aug 8. doi: 10.1111/apa.15525. Online ahead of print. PMID: 32772428

Lipoxin A4 reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea. Abma W, Noreby M, Wheelock CE, Dahlén SE, Adner M, Säfholm J. Prostaglandins Other Lipid Mediat. 2020 Aug;149:106428. doi: 10.1016/j.prostaglandins.2020.106428. Epub 2020 Feb 15. PMID: 32070748

Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy. Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M. J Allergy Clin Immunol. 2020 Aug 10:S0091-6749(20)31108-8. doi: 10.1016/j.jaci.2020.08.002. Online ahead of print. PMID: 32791163

Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer. Krstić Ristivojević M, Grundström J, Apostolović D, Radomirović M, Jovanović V, Radoi V, Kiewiet MBG, Vukojević V, Ćirković Veličković T, van Hage M. Int J Mol Sci. 2020 Aug 11;21(16):E5742. doi: 10.3390/ijms21165742. PMID: 32796496

Exposure-based cognitive behavior therapy for anxiety related to asthma: A feasibility study with multivariate baseline design. Bonnert M, Andersson E, Serlachius E, Manninen IK, Bergström SE, Almqvist C. Scand J Psychol. 2020 Jul 24. doi: 10.1111/sjop.12674. Online ahead of print. PMID: 32706124

The use of short-acting beta-2 adrenergic receptor agonists for asthma increased among Finnish and Swedish children from 2006 to 2017. Kivistö JE, Karjalainen J, Huhtala H, Protudjer JLP. Acta Paediatr. 2020 Aug;109(8):1620-1626. doi: 10.1111/apa.15288. Epub 2020 Apr 23. PMID: 32259302


Upcoming conferences and meetings
in the asthma and allergy area


EUROBAT (European Consortium on Application of Flow Cytometry in Allergy), 15 October 2020, Manchester, UK

FAAM (Food Allergy and Anaphylaxis Meeting), 15-17 October 2020

Allergidagen, 20 October 2020

Allergidagen is a Swedish meeting organised by the SFFA (Svenska Föreningen för Allergologi). Registration is free of charge, simply email and a link for viewing will be provided.

ISAF (International Severe Asthma Forum), 22-24 October 2020

Postponed to 30 June-2 July 2021: 8th European Workshop on Lipid Mediators, Stockholm, Sweden


About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy.

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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Anna James
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