Recent publications by CfA researchers
The CfA congratulates Johan Kolmert and collegues on their important publication in the blue journal, regarding the use of urinary eicosanoids to identify patients with a particular phenotype of asthma driven by eosinophilic inflammation. There is also an editorial to accompany written by Stokes Peebles, see below. Well done Johan!
Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group. Am J Respir Crit Care Med. 2020 Jul 15. doi: 10.1164/rccm.201909-1869OC. Online ahead of print. PMID: 32667261
Urine - A Lens for Asthma Pathogenesis and Treatment? Peebles RS Jr.Am J Respir Crit Care Med. 2020 Aug 13. doi: 10.1164/rccm.202007-2899ED. Online ahead of print.PMID: 32791002 No abstract available
Associations between food allergy and perceived life status. Middelveld R, Gunnarsson NV, Ahlstedt S, Protudjer JLP.Ann Allergy Asthma Immunol. 2020 Jul 24:S1081-1206(20)30513-5. doi: 10.1016/j.anai.2020.07.021. Online ahead of print.PMID: 32717299
eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy. Abdel-Aziz MI, Brinkman P, Vijverberg SJH, Neerincx AH, de Vries R, Dagelet YWF, Riley JH, Hashimoto S, Chung KF, Djukanovic R, Fleming LJ, Murray CS, Frey U, Bush A, Singer F, Hedlin G, Roberts G, Dahlén SE, Adcock IM, Fowler SJ, Knipping K, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH; U-BIOPRED Study Group; Amsterdam UMC Breath Research Group. J Allergy Clin Immunol. 2020 Jun 10:S0091-6749(20)30808-3. doi: 10.1016/j.jaci.2020.05.038. Online ahead of print. PMID: 32531371
A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig. Ramos-Ramírez P, Noreby M, Liu J, Ji J, Abdillahi SM, Olsson H, Dahlén SE, Nilsson G, Adner M. Clin Exp Allergy. 2020 Jul 21. doi: 10.1111/cea.13713. Online ahead of print. PMID: 32691918
YKL-40 is a proposed biomarker of inflammation and remodelling elevated in children with bronchopulmonary dysplasia compared to asthma. James AJ, Nordlund B, Konradsen JR, Ebersjö C, Dahlén SE, Berggren Broström E, Hedlin G. Acta Paediatr. 2020 Aug 8. doi: 10.1111/apa.15525. Online ahead of print. PMID: 32772428
Lipoxin A4 reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea. Abma W, Noreby M, Wheelock CE, Dahlén SE, Adner M, Säfholm J. Prostaglandins Other Lipid Mediat. 2020 Aug;149:106428. doi: 10.1016/j.prostaglandins.2020.106428. Epub 2020 Feb 15. PMID: 32070748
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy. Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M. J Allergy Clin Immunol. 2020 Aug 10:S0091-6749(20)31108-8. doi: 10.1016/j.jaci.2020.08.002. Online ahead of print. PMID: 32791163
Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer. Krstić Ristivojević M, Grundström J, Apostolović D, Radomirović M, Jovanović V, Radoi V, Kiewiet MBG, Vukojević V, Ćirković Veličković T, van Hage M. Int J Mol Sci. 2020 Aug 11;21(16):E5742. doi: 10.3390/ijms21165742. PMID: 32796496
Exposure-based cognitive behavior therapy for anxiety related to asthma: A feasibility study with multivariate baseline design. Bonnert M, Andersson E, Serlachius E, Manninen IK, Bergström SE, Almqvist C. Scand J Psychol. 2020 Jul 24. doi: 10.1111/sjop.12674. Online ahead of print. PMID: 32706124
The use of short-acting beta-2 adrenergic receptor agonists for asthma increased among Finnish and Swedish children from 2006 to 2017. Kivistö JE, Karjalainen J, Huhtala H, Protudjer JLP. Acta Paediatr. 2020 Aug;109(8):1620-1626. doi: 10.1111/apa.15288. Epub 2020 Apr 23. PMID: 32259302
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