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The Centre for Allergy Research

Newsletter 6th November 2020

 

Congratulations, Sir Stephen Holgate!

 

The CfA would like to congratulate our friend and colleague, Professor Stephen Holgate on receiving a knighthood for his services to medical research. Stephen Holgate was one of the founding members of the European severe asthma studies ENFUMOSA, and subsequently BIOAIR, both of which CfA members have been heavily involved in and which have led to, and continue to lead to, important discoveries within the field. To read more about Stephen Holgate click here.

 

Well done to the AsthmaTuner team

 

Björn Nordlund, Henrik Ljungberg, Anna Carleborg och Martine Isachsen, on winning this years Athena prize for their smartphone spirometer app, read the full article in Dagens Medicin. This device will help patients with asthma to monitor their own lung function.

Foto: Erik Simander/Bildbyrån

 

Funding opportunities

The Konsul Th C Berghs foundation supports research within the field of allergy and donates yearly stipends of approximately 1 million SEK in total to allergy-researchers active in Sweden. A special grant of 100 000 SEK is granted to one scientist who recieved their PhD during 2019/2020. Deadline:14th December 2020. For more information click the link above or contact marthe.niemi@konsulbergh.se

Apply now for an ERS Long-Term Research Fellowship 2021. The application deadline is 4th January 2021 and provides an opportunity for early career investigators, clinicians and allied health professionals to boost their careers in basic, translational and clinical research.

The Swedish Society for Medical Research (SSMF) is currently providing postdoctoral funding, deadline 15th November 2020. This call is primarily for young medical researchers who recieved a PhD no longer than 3 years ago. The applicant must have held a research position in Sweden for a year, and also have the intention to continue with research in Sweden after the postdoctoral period.

The Apotekare Hedbergs Stiftelse research grant, deadline 16th November 2020, is primarily for research on inflammatory disease and grants are provided in the region of 50 000 - 100 000 SEK.

 

Recent publications by CfA researchers

 

Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2 LEN study.Blöndal V, Malinovschi A, Sundbom F, James A, Middelveld R, Franklin KA, Lundbäck B, Janson C. Clin Exp Allergy. 2020 Oct 14.

Allergic disease and risk of stress in pregnant women: a PreventADALL study. Olsson Mägi CA, Bjerg Bäcklund A, Lødrup Carlsen K, Almqvist C, Carlsen KH, Granum B, Haugen G, Hilde K, Lødrup Carlsen OC, Jonassen CM, Rehbinder EM, Sjøborg KD, Skjerven H, Staff AC, Vettukattil R, Söderhäll C, Nordlund B. ERJ Open Res. 2020 Oct 13;6(4):00175-2020.

Acetaminophen and asthma, a bitter pill to swallow? Bjerg A. J Allergy Clin Immunol. 2020 Sep 25:S0091-6749(20)31326-9.

Asthma and all-cause mortality in children and young adults: a population-based study. Caffrey Osvald E, Bower H, Lundholm C, Larsson H, Brew BK, Almqvist C. Thorax. 2020 Sep 22:thoraxjnl-2020-214655.

High anxiety and health-related quality of life in families with children with food allergy during coronavirus disease 2019. Protudjer JLP, Golding M, Salisbury MR, Abrams EM, Roos LE. Ann Allergy Asthma Immunol. 2020 Sep 18:S1081-1206(20)31009-7.

Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2. Wahlund CJE, Gucluler Akpinar G, Steiner L, Ibrahim A, Bandeira E, Lepzien R, Lukic A, Smed-Sörensen A, Kullberg S, Eklund A, Grunewald J, Gabrielsson S. Sci Rep. 2020 Sep 18;10(1):15328.

Shorter time to clinical decision in work-related asthma using a digital tool. Bjerg A, Ljungberg H, Dierschke K, Åkerberg-Krook E, Andersson UBK, Olin AC, Lindberg E, Yuan X, Lyström J, Wålinder R, Victor S, Andersson M, Bertilsson H, Carleborg A, Nordlund B. ERJ Open Res. 2020 Sep 14;6(3):00259-2020.

Air pollution and IgE sensitization in 4 European birth cohorts-the MeDALL project. Melén E, Standl M, Gehring U, Altug H, Antó JM, Berdel D, Bergström A, Bousquet J, Heinrich J, Koppelman GH, Kull I, Lupinek C, Markevych I, Schikowski T, Thiering E, Valenta R, van Hage M, von Berg A, Vonk JM, Wickman M, Wijga A, Gruzieva O. J Allergy Clin Immunol. 2020 Sep 11:S0091-6749(20)31241-0.

Paternal DNA Methylation May Be Associated With Gestational Age at Birth. Luo R, Mukherjee N, Chen S, Jiang Y, Arshad SH, Holloway JW, Hedman A, Gruzieva O, Andolf E, Pershagen G, Almqvist C, Karmaus WJ. Epigenet Insights. 2020 Sep 10;13:2516865720930701.

Chronic Airway Allergy Induces Pro-Inflammatory Responses in the Brain of Wildtype Mice but Not 3xTgAD Mice. Sarlus H, Codita A, Wang X, Cedazo-Minguez A, Schultzberg M, Oprica M. Neuroscience. 2020 Nov 10;448:14-27.

Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics. Zounemat Kermani N, Saqi M, Agapow P, Pavlidis S, Kuo C, Tan KS, Mumby S, Sun K, Loza M, Baribaud F, Sousa AR, Riley J, Wheelock AM, Wheelock CE, De Meulder B, Schofield J, Sánchez-Ovando S, Simpson JL, Baines KJ, Wark PA, Auffray C, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Guo YK, Chung KF; U-BIOPRED Project Team. Allergy. 2020 Aug 31.

Epigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients. Acevedo N, Benfeitas R, Katayama S, Bruhn S, Andersson A, Wikberg G, Lundeberg L, Lindvall JM, Greco D, Kere J, Söderhäll C, Scheynius A. Sci Rep. 2020 Oct 22;10(1):18020.

Association between atopic dermatitis and autoimmune diseases: a population-based case-control study. Ivert LU, Wahlgren CF, Lindelöf B, Dal H, Bradley M, Johansson EK. Br J Dermatol. 2020 Oct 22.

Chromatin Interactions in Differentiating Keratinocytes Reveal Novel Atopic Dermatitis and Psoriasis-Associated Genes. Sahlén P, Spalinskas R, Asad S, Mahapatra KD, Höjer P, Anil A, Eisfeldt J, Srivastava A, Nikamo P, Mukherjee A, Kim KH, Bergman O,d Ståhle M, Sonkoly E, Pivarcsi A, Wahlgren CF, Nordenskjöld M, Taylan F, Bradley M, Tapia-Páez I. J Allergy Clin Immunol. 2020 Oct 16:S0091-6749(20)31410-X.

Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites. Ottman N, Barrientos-Somarribas M, Fyhrquist N, Alexander H, Wisgrill L, Olah P, Tsoka S, Greco D, Levi-Schaffer F, Soumelis V, Schröder JM, Kere J, Nestle FO, Barker J, Ranki A, Lauerma A, Homey B, Andersson B, Alenius H. Allergy. 2020 Oct 1.

Weight gain in patients with severe atopic dermatitis treated with dupilumab: a cohort study. Johansson EK, Ivert LU, Bradley B, Lundqvist M, Bradley M. BMC Dermatol. 2020 Sep 22;20(1):8.

No evidence for a placental microbiome in human pregnancies at term. Sterpu I, Fransson E, Hugerth LW, Du J, Pereira M, Cheng L, Radu SA, Calderón-Pérez L, Zha Y, Angelidou P, Pennhag A, Boulund F, Scheynius A, Engstrand L, Wiberg-Itzel E, Schuppe-Koistinen I. Am J Obstet Gynecol. 2020 Aug 29:S0002-9378(20)30984-4.

Exposure to environmental phthalates during preschool age and obesity from childhood to young adulthood. Zettergren A, Andersson N, Larsson K, Kull I, Melén E, Georgelis A, Berglund M, Lindh C, Bergström A. Environ Res. 2020 Sep 24;192:110249.

On Genetics, Lung Developmental Biology, and Adult Lung Function. Melén E, Koppelman GH, Guerra S. Am J Respir Crit Care Med. 2020 Sep 15;202(6):791-793. doi: 10.1164/rccm.202006-2123ED.

Smoking-associated increase in mucins 1 and 4 in human airways. Merikallio H, Kaarteenaho R, Lindén S, Padra M, Karimi R, Li CX, Lappi-Blanco E, Wheelock ÅM, Sköld MC. Respir Res. 2020 Sep 18;21(1):239.

IL-36 Cytokines Promote Inflammation in the Lungs of Long-term Smokers. Kovach MA, Che K, Brundin B, Andersson A, Asgeirsdottir H, Padra M, Lindén SK, Qvarfordt I, Newstead MW, Standiford TJ, Lindén A. Am J Respir Cell Mol Biol. 2020 Oct 26.

Type 2 Inflammatory Shift in Chronic Rhinosinusitis During 2007-2018 in Belgium. Karin J, Tim D, Gabriele H, Cardell LO, Marit W, Claus B. Laryngoscope. 2020 Sep 23.

 

Upcoming conferences and meetings
in the asthma and allergy area

 

The popular ERS Lung Science Conference 2021 will go ahead as a virtual event from 11–12 March focusing on repair and regeneration in chronic lung disease and lung cancer. Abstracts can be submitted until the extended deadline of 15 December, 2020.

The American Thoracic Society (ATS) is planning to hold a hybrid annual conference in San Diego, 14-19 May 2021. The deadline for abstract submission is 16th december 2020.

The European Academy of Allergy and Clinical Immunology (EAACI) will be hosting a digital winter school on basic immunology research on the 22-24 January 2021. EAACI will also be hosting a hybrid annual conference in both Krakow and Madrid on the 10-12 July 2021, deadline for abstract submission is 1st Feb 2021.

Postponed to 30 June-2 July 2021: 8th European Workshop on Lipid Mediators, Stockholm, Sweden

 

About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy. ki.se/cfa

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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Anna James
kontakt: ki.se/cfa e-mail: cfa@imm.ki.se

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