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The Centre for Allergy Research

Newsletter 18 December 2020

The Centre for Allergy Research

wishes you all a very Merry Christmas and a

Happy 2021!

CfA members receive funding from Astma och Allergiförbundet

 

The Swedish Asthma and Allergy Research Foundation provides financial support to scientists carrying out research on asthma, allergy and other types of hypersensitivty and welcomes applications every year. During 2020 they also announced a special call aimed to bridge important knowledge gaps. We congratulate our CfA colleagues:

Catarina Almqvist Malmros for her project on food allergy and stress
Inger Kull for her project on young adults coping with food allergies
Caroline Nilsson for her project on treatment of paediatric eosinophilic oesophagitis
Anna Sandin for her project on salivary bacteria and thier relation to food allergy
Anna Asarnoj for her work on immunotherapy for peanut allergy in young children
Cilla Söderhäll for longitudinal investigations of risk factors for chronic childhood asthma
Marit Westman for studying chronic rhinosinusitis and the link between upper and lower
Christer Janson for studying asthma & allergy development in the aging Nordic population
Andrei Malinovschi for studying methods to examine small airway involvement in asthma
Eva Sverremark-Ekström for examining the relationship between gut flora and allergy

KI researchers discover new biomarkers to improve diagnosis of contact allergy!

 

Click here to read more about the discovery made by corresponding author Nanna Fyhrquist and her team from the Institute of Environmental medicine. This important finding published in PNAS will help to differentiate irritant eczema from contact allergy.

 

Nanna Fyhrquist. Foto: Stefan Zimmerman

Forthcoming seminars

Astma och Allergiförbundet will be organising a one-day virtual event on the 17th March 2021 focusing on development of a new national allergy program. For more information and registration click here.

The European Mast Cell and Basophil Research Network (EMBRN) will be hosting a series of 90-minute webinars, every 2-3 months, starting on Monday 11th January 2021 at 17:00. The theme of the first webinar is Mast cells as targets for novel treatments (Chair: Prof. Marcus Maurer). For more information and registration click here.

Recent publications by CfA researchers

 

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation. Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group.Am J Respir Crit Care Med. 2020 Jul 15. doi: 10.1164/rccm.201909-1869OC. Online ahead of print.PMID: 32667261

Associations between food allergy and perceived life status. Middelveld R, Gunnarsson NV, Ahlstedt S, Protudjer JLP. Ann Allergy Asthma Immunol. 2020 Dec;125(6):703-705.e1. doi: 10.1016/j.anai.2020.07.021. Epub 2020 Jul 24. PMID: 32717299

Interleukin-26 in host defense and inflammatory disorders of the airways. Che KF, Tengvall S, Lindén A. Cytokine Growth Factor Rev. 2020 Nov 18:S1359-6101(20)30217-3. doi: 10.1016/j.cytogfr.2020.10.003. Online ahead of print. PMID: 33293237

The ratio FEV1 /FVC and its association to respiratory symptoms - a Swedish general population study.Torén K, Schiöler L, Lindberg A, Andersson A, Behndig AF, Bergström G, Blomberg A, Caidahl K, Engvall JE, Eriksson MJ, Hamrefors V, Janson C, Kylhammar D, Lindberg E, Lindén A, Malinovschi A, Lennart Persson H, Sandelin M, Eriksson Ström J, Tanash H, Vikgren J, Johan Östgren C, Wollmer P, Magnus Sköld C. Clin Physiol Funct Imaging. 2020 Dec 7. doi: 10.1111/cpf.12684. Online ahead of print. PMID: 33284499

Developments allergy in 2019 through the eyes of clinical and experimental allergy, part I mechanisms.Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA. Clin Exp Allergy. 2020 Dec;50(12):1294-1301. doi: 10.1111/cea.13777. PMID: 33283368

Sesame allergy a time burden for families of children with multiple food allergies.Lemoine-Courcelles C, Abrams EM, Kim H, Povolo B, Gerdts BComm J, Penner Protudjer JL. J Allergy Clin Immunol Pract. 2020 Nov 26:S2213-2198(20)31252-6. doi: 10.1016/j.jaip.2020.11.031. Online ahead of print. PMID: 33249122

Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.Ramos-Ramírez P, Malmhäll C, Johansson K, Adner M, Lötvall J, Bossios A. Int J Mol Sci. 2020 Nov 26;21(23):8990. doi: 10.3390/ijms21238990. PMID: 33256137

A pilot study towards the immunological effects of omalizumab treatment used to facilitate oral immunotherapy in peanut allergic adolescents. van der Heiden M, Nopp A, Brandström J, Carvalho-Queiroz C, Nilsson C, Sverremark-Ekström E. Scand J Immunol. 2020 Nov 27:e13005. doi: 10.1111/sji.13005. Online ahead of print. PMID: 33244763

The Swedish National Airway Register (SNAR): development, design and utility to date.Stridsman C, Konradsen JR, Vanfleteren L, Pedroletti C, Binnmyr J, Edfelt P, Fjällman Schärberg K, Sjöö Y, Nyberg F, Lindberg A, Tunsäter A, Ekberg-Jansson A. Eur Clin Respir J. 2020 Oct 23;7(1):1833412. doi: 10.1080/20018525.2020.1833412. PMID: 33224453

Race/ethnicity, but not income, are associated with increased odds of shellfish allergy.Abrams EM, Gerdts JD, Gruber J, Lemoine-Courcelles C, Simons E, Protudjer JLP. J Allergy Clin Immunol Pract. 2020 Nov 16:S2213-2198(20)31221-6. doi: 10.1016/j.jaip.2020.11.003. Online ahead of print. PMID: 33212240

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure.Merid SK, Bustamante M, Standl M, Sunyer J, Heinrich J, Lemonnier N, Aguilar D, Antó JM, Bousquet J, Santa-Marina L, Lertxundi A, Bergström A, Kull I, Wheelock ÅM, Koppelman GH, Melén E, Gruzieva O. Environ Int. 2020 Nov 16;146:106248. doi: 10.1016/j.envint.2020.106248. Online ahead of print. PMID: 33212358

Elucidating the α-Gal syndrome at the molecular allergen level.Kiewiet MG, Grundström J, Apostolovic D, Andersson M, Borres MP, Hamsten C, Starkhammar M, van Hage M. Allergy. 2020 Nov 18. doi: 10.1111/all.14660. Online ahead of print. PMID: 33206401

Assessment of chronic bronchitis and risk factors in young adults: Results from BAMSE.Wang G, Hallberg J, Um Bergström P, Janson C, Pershagen G, Gruzieva O, van Hage M, Georgelis A, Bergström A, Kull I, Lindén A, Melén E. Eur Respir J. 2020 Nov 12:2002120. doi: 10.1183/13993003.02120-2020. Online ahead of print. PMID: 33184115

Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort.Wang G, Kull I, Bergström A, Hallberg J, Bergström PU, Guerra S, Pershagen G, Gruzieva O, van Hage M, Georgelis A, Janson C, Lindén A, Melén E. Thorax. 2020 Nov 12:thoraxjnl-2020-215884. doi: 10.1136/thoraxjnl-2020-215884. Online ahead of print. PMID: 33184098

Adult and Pediatric Food Allergy to Chickpea, Pea, Lentil, and Lupine: A Scoping Review.Hildebrand HV, Arias A, Simons E, Gerdts J, Povolo B, Rothney J, Protudjer JLP. J Allergy Clin Immunol Pract. 2020 Nov 6:S2213-2198(20)31200-9. doi: 10.1016/j.jaip.2020.10.046. Online ahead of print. PMID: 33166732

Upcoming conferences and meetings
in the asthma and allergy area

 

Frauenhofer special edition seminar, Models of Lung Disease – special edition "Corona", 21-22 January 2021, virtual conference

EAACI Winter School 2021 Basic Immunology Research in Allergy and Clinical Immunology, 22-24 January 2021, digital event

EAACI ISAF (International Severe Asthma Forum), date to be announced during Jan or Feb 2021, digital event

AAAAI Annual Meeting, 26 Feb - 1 March, 2021, virtual event

ERS 19th Lung Science Conference - Repair and regeneration in chronic lung disease and lung cancer, 11-12 March 2021, virtual event

EAACI SAM (Skin Allergy Meeting), 12-13 March 2021, digital event

ATS International Conference, 14-19 May 2021, San Diego, USA

EAACI Hybrid Congress, 10-12 June 2021, Krakow, Poland and Madrid, Spain

8th European Workshop on Lipid Mediators, 30 June - 2 July 2021, Karolinska Institutet, Stockholm, Sweden

ERS International Congress, 4-8 September 2021, Barcelona, Spain

About the Centre for Allergy Research
The Centre for Allergy Research (CfA) is a centre of excellence at Karolinska Institutet. Our aim is to improve treatment and care of individuals with asthma and allergy. ki.se/cfa

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The Centre for Allergy Research / Centrum för Allergiforskning
Director: Sven-Erik Dahlén, Director Clinical Research: Gunilla Hedlin,
Project Manager: Anna James
kontakt: ki.se/cfa e-mail: cfa@imm.ki.se

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