The Swedish Lung Congress (SLK) 2021

The Swedish lung congress (Svenska Lungkongressen) is planned to take place in Umeå this year on the 4-6 May, as a hybrid event where hopefully both online and actual participation will be possible.

For more information and registration click here

Places still available on Psychoneuroimmunology course

There are a few spots available on the doctoral course “Psychoneuroimmunology” (click here to apply) that will be held on March 15th to April 1st.

This course aims to provide an overview of present knowledge in Psychoneuroimmunology and to offer an opportunity to apply a interdisciplinary mechanistic perspective across physiological and pathological conditions. Students are given good opportunities to network and to interact with leading national and international researchers in Psychoneuroimmunology.

Forthcoming international conferences in the asthma and allergy field

AAAAI Annual Meeting, 26 Feb - 1 March, 2021, virtual event

EAACI ISAF (International Severe Asthma Forum), 17 April 2021, digital event

ERS 19th Lung Science Conference - Repair and regeneration in chronic lung disease and lung cancer, 11-12 March 2021, virtual event

EAACI SAM (Skin Allergy Meeting), 12-13 March 2021, digital event

ATS International Conference, 14-19 May 2021, San Diego, USA

EAACI Hybrid Congress, 10-12 June 2021, Krakow, Poland and Madrid, Spain

8th European Workshop on Lipid Mediators, 30 June - 2 July 2021, Karolinska Institutet, Stockholm, Sweden

ERS International Congress, 4-8 September 2021, Barcelona, Spain

Funding opportunities

Type 2 Innovation Grant 2021

Sanofi Genzyme will be providing support for independent, novel and innovative research projects investigating type 2 immune-mediated diseases, such as atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) or other type 2 immune-mediate diseases with relevance in clinical practice. The ten most relevant projects, 5 in Dermatology and 5 in Respiratory, will receive a one-time research grant of up to EUR 80,000. Apllication platform open until 31st May 2021.

Marie Sklodowska-Curie Postdoctoral Research Fellowships (RESPIRE)

The European Respiratory Society’s (ERS) RESPIRE fellowship programme offers a platform for early career researchers develop their skills in an international environment and supports fellows on their journey to becoming future leaders in the respiratory field. Application deadline is 1st May, 2021, and open to researchers with a PhD or four years full-time research experience from any discipline.

Recent publications by CfA researchers

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation. Delgado-Eckert E, James A, Meier-Girard D, Kupczyk M, Andersson LI, Bossios A, Mikus M, Junya O, Kenji I, Middelveld R, Dahlén B, Gaga M, Siafakas NM, Papi A, Beghe B, Joos G, Rabe KF, Sterk PJ, Bel EH, Johnston SL, Chanez P, Gjomarkaj M, Howarth PH, Niżankowska-Mogilnicka E, Dahlén SE, Frey U. J Allergy Clin Immunol. 2021 Feb 3:S0091-6749(21)00162-7.

COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells. Johnsson AK, Rönnberg E, Fuchs D, Kolmert J, Säfholm J, Claesson HE, Hamberg M, Wheelock CE, Nilsson G, Dahlén SE. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan 13;1866(5):158886.

Selective inhibition of prostaglandin D2 biosynthesis in human mast cells to overcome need for multiple receptor antagonists: Biochemical consequences.Johnsson AK, Choi JH, Rönnberg E, Fuchs D, Kolmert J, Hamberg M, Dahlén B, Wheelock CE, Dahlén SE, Nilsson G. Clin Exp Allergy. 2021 Jan 15.

Idiopathic Anaphylaxis: a Perplexing Diagnostic Challenge for Allergists. Gulen T, Akin C. Curr Allergy Asthma Rep. 2021 Feb 9;21(2):11.

Peanuts in the air clinical and experimental studies. Lovén Björkman S, Sederholm U, Ballardini N, Beck O, Lundahl J, Nopp A, Nilsson C. Clin Exp Allergy. 2021 Feb 6.

Resolved allergen specific IgE sensitization among females and early poly-sensitization among males impact IgE sensitization up to age 24 years. Ballardini N, Bergström A, Kull I, Almqvist C, Andersson N, Asarnoj A, Borres MP, Georgellis A, Pershagen G, Westman M, van Hage M, Melén E. Clin Exp Allergy. 2021 Feb 6.

A randomized, open-label trial of hen's egg oral immunotherapy: efficacy and humoral immune responses in 50 children. Palosuo K, Karisola P, Savinko T, Fyhrquist N, Alenius H, Mäkelä MJ. J Allergy Clin Immunol Pract. 2021 Jan 30:S2213-2198(21)00078-7.

Effect of maternal asthma exacerbations on perinatal outcomes: a population-based study. Robijn AL, Brew BK, Jensen ME, Rejnö G, Lundholm C, Murphy VE, Almqvist C. ERJ Open Res. 2020 Dec 21;6(4):00295-2020.

Mothers of children with food allergies report poorer perceived life status which may be explained by limited career choices. Frykas TLM, Golding M, Abrams EM, Simons E, Protudjer JLP. Allergy Asthma Clin Immunol. 2021 Feb 1;17(1):12.

Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma. Mendez-Enriquez E, Alvarado-Vazquez PA, Abma W, Simonson OE, Rodin S, Feyerabend TB, Rodewald HR, Malinovschi A, Janson C, Adner M, Hallgren J. Allergy. 2021 Jan 24.

Interplay between skin microbiota and immunity in atopic individuals. Riskumäki M, Tessas I, Ottman N, Suomalainen A, Werner P, Karisola P, Lauerma A, Ruokolainen L, Karkman A, Wisgrill L, Sinkko H, Lehtimäki J, Alenius H, Fyhrquist N. Allergy. 2021 Jan 22.

DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life. Acevedo N, Scala G, Merid SK, Frumento P, Bruhn S, Andersson A, Ogris C, Bottai M, Pershagen G, Koppelman GH, Melén E, Sonnhammer E, Alm J, Söderhäll C, Kere J, Greco D, Scheynius A. Int J Mol Sci. 2021 Jan 14;22(2):801.

Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma. Abdel-Aziz MI, Kermani NZ, Neerincx AH, Vijverberg SJH, Guo Y, Howarth P, Dahlen SE, Djukanovic R, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH, Chung KF, Adcock IM; On behalf the U-BIOPRED Consortium. Allergy. 2021 Jan 7.

Impact of age on adherence and efficacy of peanut oral-immunotherapy using a standardized protocol. Zhu R, Robertson K, Protudjer JLP, Macikunas A, Kim R, Jeimy S, Kim H. Pediatr Allergy Immunol. 2021 Jan 7.

Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19. Larsson SC, Gill D. Allergy. 2020 Dec 31.

Genetic effects of allergen-specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study. Hedman AM, Kuja-Halkola R, Örtqvist AK, van Hage M, Almqvist C, Nordlund B. Pediatr Allergy Immunol. 2020 Dec 22.

Shared DNA methylation signatures in childhood allergy: The MeDALL study.Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G; BIOS Consortium, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. J Allergy Clin Immunol. 2020 Dec 15:S0091-6749(20)31766-8.

Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis. Fortino V, Wisgrill L, Werner P, Suomela S, Linder N, Jalonen E, Suomalainen A, Marwah V, Kero M, Pesonen M, Lundin J, Lauerma A, Aalto-Korte K, Greco D, Alenius H, Fyhrquist N. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33474-33485.

The ratio FEV1 /FVC and its association to respiratory symptoms-A Swedish general population study. Torén K, Schiöler L, Lindberg A, Andersson A, Behndig AF, Bergström G, Blomberg A, Caidahl K, Engvall JE, Eriksson MJ, Hamrefors V, Janson C, Kylhammar D, Lindberg E, Lindén A, Malinovschi A, Lennart Persson H, Sandelin M, Eriksson Ström J, Tanash H, Vikgren J, Johan Östgren C, Wollmer P, Sköld CM. Clin Physiol Funct Imaging. 2021 Mar;41(2):181-191.

Maternal Intake of Cow's Milk during Lactation Is Associated with Lower Prevalence of Food Allergy in Offspring. Stråvik M, Barman M, Hesselmar B, Sandin A, Wold AE, Sandberg AS.Nutrients. 2020 Nov 28;12(12):3680.

Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation.Ramos-Ramírez P, Malmhäll C, Johansson K, Adner M, Lötvall J, Bossios A. Int J Mol Sci. 2020 Nov 26;21(23):8990.

Sesame allergy a time burden for families of children with multiple food allergies.Lemoine-Courcelles C, Abrams EM, Kim H, Povolo B, Gerdts J, Protudjer JLP. J Allergy Clin Immunol Pract. 2020 Nov 27:S2213-2198(20)31252-6.

Air pollution and IgE sensitization in 4 European birth cohorts-the MeDALL project. Melén E, Standl M, Gehring U, Altug H, Antó JM, Berdel D, Bergström A, Bousquet J, Heinrich J, Koppelman GH, Kull I, Lupinek C, Markevych I, Schikowski T, Thiering E, Valenta R, van Hage M, von Berg A, Vonk JM, Wickman M, Wijga A, Gruzieva O.J Allergy Clin Immunol. 2021 Feb;147(2):713-722

Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma. Talaei M, Sdona E, Calder PC, Jones LR, Emmett PM, Granell R, Bergström A, Melén E, Shaheen SO.Eur Respir J. 2021 Jan 28:2003633.

Maternal use of nicotine products and breastfeeding 3 months postpartum. Nordhagen LS, Kreyberg I, Bains KES, Carlsen KH, Glavin K, Skjerven HO, Småstuen MC, Hilde K, Nordlund B, Vettukattil R, Hedlin G, Granum B, Jonassen CM, Gudmundsdóttir HK, Haugen G, Rehbinder EM, Söderhäll C, Staff AC, Lødrup Carlsen KC; PreventADALL study group.Acta Paediatr. 2020 Dec;109(12):2594-2603.

Preschool wheezing and asthma in children: A systematic review of guidelines and quality appraisal with the AGREE II instrument. Ruszczyński M, Ambrożej D, Adamiec A, Ryczaj K, Elenius V, Cavkaytar O, Maggina P, Makrinioti H, Papadopoulos N, Hedlin G, Konradsen JR, Schaub B, H Smits H, Jartti T, Feleszko W; EAACI Task Force on Clinical Practice Recommendations on Preschool Wheeze. Pediatr Allergy Immunol. 2021 Jan;32(1):92-105.

Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial. Skjerven HO, Rehbinder EM, Vettukattil R, LeBlanc M, Granum B, Haugen G, Hedlin G, Landrø L, Marsland BJ, Rudi K, Sjøborg KD, Söderhäll C, Staff AC, Carlsen KH, Asarnoj A, Bains KES, Carlsen OCL, Endre KMA, Granlund PA, Hermansen JU, Gudmundsdóttir HK, Hilde K, Håland G, Kreyberg I, Olsen IC, Mägi CO, Nordhagen LS, Saunders CM, Skrindo I, Tedner SG, Værnesbranden MR, Wiik J, Jonassen CM, Nordlund B, Carlsen KCL. Lancet. 2020 Mar 21;395(10228):951-961.