Congratulations to all CfA colleagues for a very productive year!

At least 65 articles were published during 2021 on the subject of allergy by authors affiliated to the Karolinska Institute and Karolinska University Hospital, see the complete list here. Among others, some highlights include important and timely findings on COVID-19 in young adults with asthma by the BAMSE study group, epidemiological findings on early life stress and the later development of allergic disease in the next generation, urinary eicosanoids as type 2 biomarkers and new plasma biomarkers as non-type 2 biomarkers in severe asthma by the U-BIOPRED, SWEDISH SEARCH and BIOAIR study groups, and most recently, novel findings on impaired skin barrier and allergic sensitization by the PreventADALL study group.

Upcoming conferences and meetings
in the asthma and allergy area

EAACI WINTER SCHOOL 27-30 Jan 2022 on basic immunology research in allergy and clinical immunology. Hybrid meeting, Semmering, Austria

AAAAI Annual Meeting, 25-28 Febuary 2022, Phoenix, Arizona, USA

American Thoracic Society 13-18 May 2022, San Francisco, CA, USA.

Collegium Internationale Allergologicum (CIA) symposium, 22-26 May, 2022, entitled Shifting Paradigms in Allergy and Immune Disease: Diagnosis & Management will be held in Montréal, Quebec

The 20th Fraunhofer Seminar “Models of Lung Disease” will take place at the CRC Hannover from June 23 to 24, 2022.

8th European Workshop on Lipid Mediators, 29 June - 1 July 2022, Stockholm, Sweden

EAACI 1-3 July 2022, Hybrid meeting, Prague, Czech Republic

European Respiratory Society 4-6 September 2022, Barcelona, Spain

ERS Lung Science Conference 2022. Mucosal immunology of the lung: balancing protective immunity and chronic inflammation. 10–13 March, 2022, Estoril, Portugal

Recent publications by CfA researchers

Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study. Wang G, Hallberg J, Charalampopoulos D, Sanahuja MC, Breyer-Kohansal R, Langhammer A, Granell R, Vonk JM, Mian A, Olvera N, Laustsen LM, Rönmark E, Abellan A, Agusti A, Arshad SH, Bergström A, Boezen HM, Breyer MK, Burghuber O, Bolund AC, Custovic A, Devereux G, Donaldson GC, Duijts L, Esplugues A, Faner R, Ballester F, Garcia-Aymerich J, Gehring U, Haider S, Hartl S, Backman H, Holloway JW, Koppelman GH, Lertxundi A, Holmen TL, Lowe L, Mensink-Bout SM, Murray CS, Roberts G, Hedman L, Schlünssen V, Sigsgaard T, Simpson A, Sunyer J, Torrent M, Turner S, Van den Berge M, Vermeulen RCH, Vikjord SAA, Wedzicha JA, Maitland van der Zee AH, Melén E.ERJ Open Res. 2021 Dec 6;7(4):00457-2021.

Food allergy and hypersensitivity reactions in children and adults - a review. Tedner SG, Asarnoj A, Thulin H, Westman M, Konradsen JR, Nilsson C.J Intern Med. 2021 Dec 7. doi: 10.1111/joim.13422. Online ahead of print.

Multiomics integration-based molecular characterizations of COVID-19. Li CX, Gao J, Zhang Z, Chen L, Li X, Zhou M, Wheelock ÅM.Brief Bioinform. 2021 Dec 2:bbab485. doi: 10.1093/bib/bbab485. Online ahead of print.

The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study. Voraphani N, Stern DA, Zhai J, Wright AL, Halonen M, Sherrill DL, Hallberg J, Kull I, Bergström A, Murray CS, Lowe L, Custovic A, Morgan WJ, Martinez FD, Melén E, Simpson A, Guerra S.Lancet Respir Med. 2021 Nov 26:S2213-2600(21)00355-6. doi: 10.1016/S2213-2600(21)00355-6. Online ahead of print.

A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes. Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock ÅM, Bansal AT, Caruso M, Chanez P, Uddin M, Corfield J, Horvath I, Krug N, Musial J, Sun K, Shaw DE, Sandström T, Montuschi P, Fowler SJ, Lutter R, Djukanovic R, Howarth P, Skipp P, Sanak M, Adcock IM, Chung KF, Sterk PJ, Kraneveld AD, Maitland-van der Zee PharmD AH; U-BIOPRED Study Group.Eur Respir J. 2021 Nov 25:2102603. doi: 10.1183/13993003.02603-2021. Online ahead of print.

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. Reinke SN, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani NZ, Tiotiu A, Broadhurst DI, Lundqvist A, Olsson H, Ström M, Wheelock ÅM, Gómez C, Ericsson M, Sousa AR, Riley JH, Bates S, Scholfield J, Loza M, Baribaud F, Bakke PS, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Behndig A, Singer F, Musial J, Shaw DE, Dahlén B, Hu S, Lasky-Su J, Sterk PJ, Chung KF, Djukanovic R, Dahlén SE, Adcock IM, Wheelock CE; U-BIOPRED Study Group#.Eur Respir J. 2021 Nov 25:2101733. doi: 10.1183/13993003.01733-2021. Online ahead of print.

Association of Differential Mast Cell Activation to Granulocytic Inflammation in Severe Asthma. Tiotiu A, Badi Y, Kermani NZ, Sanak M, Kolmert J, Wheelock CE, Hansbro PM, Dahlén SE, Sterk PJ, Djukanovic R, Guo Y, Mumby S, Adcock IM, Chung KF; U-BIOPRED consortium project team.Am J Respir Crit Care Med. 2021 Nov 23. doi: 10.1164/rccm.202102-0355OC. Online ahead of print.

General Stress Among Young Adults with Asthma During the COVID-19 Pandemic. Ekström S, Mogensen I, Georgelis A, Westman M, Almqvist C, Melén E, Bergström A, Kull I; BAMSE COVID-19 Study Group.J Allergy Clin Immunol Pract. 2021 Nov 14:S2213-2198(21)01260-5. doi: 10.1016/j.jaip.2021.10.069. Online ahead of print.

Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in two TOPMed Cohorts. Kelly RS, Mendez KM, Huang M, Hobbs BD, Clish CB, Gerszten R, Cho MH, Wheelock CE, McGeachie MJ, Chu SH, Celedón JC, Weiss ST, Lasky-Su J; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.Am J Respir Crit Care Med. 2021 Nov 12. doi: 10.1164/rccm.202105-1268OC. Online ahead of print.

Impaired skin barrier and allergic sensitization in early infancy. Wärnberg Gerdin S, Lie A, Asarnoj A, Borres MP, Lødrup Carlsen KC, Färdig M, Konradsen JR, Monceyron Jonassen C, Olsson Mägi CA, Rehbinder EM, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Tedner SG, van Hage M, Vettukattil R, Nordlund B.Allergy. 2021 Nov 5. doi: 10.1111/all.15170. Online ahead of print.